Evidence map›Paper›PMID 29654491›Full record

ArticleMolecular neurobiology2018

SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke.

David T She, Lap Jack Wong, Sang-Ha Baik, Thiruma V Arumugam

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.

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  10. mMolecular neurobiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

David T SheDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9, Singapore, 117597, Singapore. bigdstw@nus.edu.sg.
Lap Jack WongDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9, Singapore, 117597, Singapore.
Sang-Ha BaikDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9, Singapore, 117597, Singapore.
Thiruma V ArumugamDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9, Singapore, 117597, Singapore. phstva@nus.edu.sg.
National University of Singapore · SG

Funding

Ministry of Education - Singapore R-185-000-285-112National Medical Research Council NMRC/CBRG/0036/2017National Medical Research Council NMRC/CBRG/0102/2016
6 · The paper itself

Abstract

Sirtuin 2 (SIRT2) is a family member of nicotinamide adenine dinucleotide (NAD

Indexed as

Down-RegulationMAP Kinase Signaling SystemNeuroprotectionAnimalsApoptosisBrain IschemiaDisease Models, AnimalForkhead Box Protein O3FuransGlucoseMaleMice, Inbred C57BLNeuronsOxygenProto-Oncogene Proteins c-aktQuinolinesAGK2 compoundForkhead Box Protein O3FoxO3 protein, mouseFuransGlucoseOxygenProto-Oncogene Proteins c-aktQuinolinesSirtuin 2AGK2AK1ApoptosisFOXO3aIschemic strokeMAPKSIRT2

Identifiers

PMID29654491
OpenAlexW2798268673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.