ArticleProbiotics and antimicrobial proteins2019
Dietary Supplementation of Probiotic Bacillus subtilis Affects Antioxidant Defenses and Immune Response in Grass Carp Under Aeromonas hydrophila Challenge.
Article in Probiotics and antimicrobial proteins, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 113 citations in OpenAlex.
- Characterization and Antibacterial Activity of a Low-Molecular-Weight Bacteriocin-like Inhibitory Substance S-2 Produced byVeterinary sciences · 2026Article
- Effect of utilizing a Bacillus sp bacteria consortium for biofilter inoculum in a lab-scale tilapia RAS to enhance production and fish health.Scientific reports · 2026Article
- DietaryAnimals : an open access journal from MDPI · 2026Article
- Probiotic Bacillus licheniformis competitively establishes and enhances production efficiency, immune responsiveness, and protection against Aeromonas hydrophila O:18 in Cirrhinus mrigala (Ham.).Scientific reports · 2026Article
- Synergistic dietary supplements of Lactobacillus brevis and trans-cinnamic acid improved growth, immune response, and disease resistance in common carp.Scientific reports · 2026Article
- Genomic and functional insights into a novel Lactococcus sp. AK05 from Cirrhinus mrigala with potent antagonism against Aeromonas hydrophila.World journal of microbiology & biotechnology · 2026Article
- Pretreatment with probiotics (Bacillus safensis NMCC-189 and Bacillus clausii) prevents epileptogenesis in mice via modulation of BBB integrity, oxidative stress, and neurotransmitter balance.Inflammopharmacology · 2025Article
- Review
- Immune protective, stress indicators, antioxidant, histopathological status, and heat shock protein gene expression impacts of dietary Bacillus spp. against heat shock in Nile tilapia, Oreochromis niloticus.BMC veterinary research · 2024Article
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- Immunostimulant, hepatoprotective, and nephroprotective potential of Bacillus subtilis (NMCC-path-14) in comparison to dexamethasone in alleviating CFA-induced arthritis.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Present Status, Limitations, and Prospects of Using Streptomyces Bacteria as a Potential Probiotic Agent in Aquaculture.Probiotics and antimicrobial proteins · 2024Review
- Evaluation of different probiotics on growth, body composition, antioxidant capacity, and histoarchitecture of Mugil capito.Scientific reports · 2024Article
- Strain-Specific Benefits ofAntioxidants (Basel, Switzerland) · 2024Article
- Dietary Effects of Probiotic Bacteria,Aquaculture nutrition · 2024Article
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- The effects of compound probiotics on production performance, rumen fermentation and microbiota ofFrontiers in veterinary science · 2024Article
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- Alterations in certain immunological parameters in the skin mucus of the carp, Cirrhinus mrigala, infected with the bacteria, Edwardsiella tarda.Fish physiology and biochemistry · 2023Article
- Effects ofBiochemistry and biophysics reports · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated whether Bacillus subtilis can provide protection for grass carp against oxidative stress damage induced by Aeromonas hydrophila. A total of 240 healthy grass carp (Ctenopharyngodon idellus) (average weight of 71.42 ± 4.36g) were randomly divided into four groups with three replicates: control group, A. hydrophila group, B. subtilis + A. hydrophila group, and A. hydrophila + B. subtilis group. After challenge with A. hydrophila, the lipid oxidative damage, antioxidant defenses, and the gene expression of inflammatory cytokines of the grass carp were investigated. Our results showed that A. hydrophila caused lipid oxidative damage, led to significant decreases in antioxidant defenses, and induced inflammatory responses of grass carp. However, the grass carp group fed the probiotic B. subtilis diet for 42 days before the challenge and the group fed the probiotic B. subtilis diet immediately after the challenge both showed (i) a reduced level of oxidative stress with a decrease in the level of MDA; (ii) an increase in antioxidant defenses, including an increase in total antioxidant capacity (T-AOC), increased activities of SOD and CAT, increased levels of GSH, and upregulated gene expression of antioxidant enzymes (SOD, CAT, and Gpx); and (iii) an improved immune response with the level of antiinflammatory cytokines IL-10 messenger RNA (mRNA) upregulated and the levels of pro-inflammatory cytokines TNF-α, IL-1β, and IL-8 mRNA downregulated. Based on this study, B. subtilis can provide effective protection of fish against oxidative stress damage induced by A. hydrophila infection.
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