Evidence map›Paper›PMID 29654445›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2020

Noninvasive estimation of quantitative myocardial blood flow with Tc-99m MIBI by a compartment model analysis in rat.

Atsutaka Okizaki, Michihiro Nakayama, Kaori Nakajima, Osuke Fujimoto, Shinobu Oshikiri, Miho Koike-Satake, Yuto Nakahara

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Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Atsutaka OkizakiDepartment of Radiology, Asahikawa Medical University, 2-1-1-1 Midorigaoka-higashi, Asahikawa, 078-8510, Japan. okizaki@asahikawa-med.ac.jp.
Michihiro NakayamaDepartment of Radiology, Asahikawa Medical University, 2-1-1-1 Midorigaoka-higashi, Asahikawa, 078-8510, Japan.
Kaori NakajimaDepartment of Radiology, Asahikawa Medical University, 2-1-1-1 Midorigaoka-higashi, Asahikawa, 078-8510, Japan.
Osuke FujimotoFujiFilm RI Pharma Co., Ltd, Tokyo, Japan.
Shinobu OshikiriFujiFilm RI Pharma Co., Ltd, Tokyo, Japan.
Miho Koike-SatakeFujiFilm RI Pharma Co., Ltd, Tokyo, Japan.
Yuto NakaharaFujiFilm RI Pharma Co., Ltd, Tokyo, Japan.
Fujifilm (Japan) · JPAsahikawa Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe aimed to investigate the use of dynamic cardiac planar images to estimate myocardial blood flow (MBF) by a compartment model analysis using time-to-peak (TP) map and compared it by the microsphere technique in rat. Positron emission tomography is considered the gold standard method, but is not available everywhere. By contrast, although myocardial perfusion imaging (MPI) with single-photon tracers is more widely available, it may be difficult to obtain adequate region of interest (ROI) settings. We proposed using the TP map to set the ROI, and hypothesized that this method could facilitate the measurement of absolute MBF by MPI in rat.

methodsTwenty-one normal rats were studied. Dynamic planar images with Tc-99m MIBI were obtained, and input function and cardiac ROIs were set using the obtained TP map. MBF was estimated by a one-compartment model analysis with the Renkin-Crone model and by the microsphere technique.

resultsThe MBFs from these two methods were significantly correlated. A negative proportional bias was observed, but no significant difference was observed between the mean MBFs calculated with each method.

conclusionsMBF estimation by a compartment model analysis using TP map could facilitate absolute MBF measurement in rats.

Indexed as

Technetium Tc 99m SestamibiAnimalsCoronary CirculationMaleMicrospheresMyocardial Perfusion ImagingRatsTechnetium Tc 99m Sestamibicompartment model analysismyocardial blood flowratsTc-99m sestamibiTP map

Identifiers

PMID29654445
OpenAlexW2797191362

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.