Observational studyEuropean journal of pediatrics2018
Characteristics of children admitted to intensive care with acute bronchiolitis.
Observational study in European journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07682844 (Impact of Outpatient Respiratory Physiotherapy on Hospitalizations and Costs in Infants With Acute Viral Bronchiolitis), which is not on this map. Cited by 74 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Outpatient Respiratory Physiotherapy on Hospitalizations and Costs in Infants With Acute Viral Bronchiolitis: A Quasi-Experimental Study in Public Health Services in Sorocaba.
Who cites it
74 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Prevalence of common respiratory viruses of infants with respiratory tract infections in European countries in the past decade: a systematic review and meta-analysis comparing between the pre-COVID-19, pandemic, and post-COVID-19 periods.European journal of pediatrics · 2026Pooled it
- Burden and Characteristics of Respiratory Syncytial Virus-Associated Bronchiolitis in Hospitalized Infants in Italy: A Systematic Review.Immunity, inflammation and disease · 2026Pooled it
- Bronchiolitis: evidence-based management in high-risk infants in the intensive care setting.Pediatric research · 2024Pooled it
- Children born preterm admitted to paediatric intensive care for bronchiolitis: a systematic review and meta-analysis.BMC pediatrics · 2023Pooled it
- Respiratory virus type to guide predictive enrichment approaches in the management of the first episode of bronchiolitis: A systematic review.Frontiers in immunology · 2022Pooled it
- Point-of-care lung ultrasound in infants with bronchiolitis in the pediatric emergency department: a prospective study.European journal of pediatrics · 2019Trial
- Modified Tal (M-Tal) Score as a Predictor of Outcomes in Infants with Bronchiolitis: A Prospective Study.Pediatric reports · 2026Article
- Long-Term Functional Outcomes After Pediatric Intensive Care Unit Admission for Bronchiolitis: A 12-Month Cohort Study.Children (Basel, Switzerland) · 2026Article
- Cost-Effectiveness of Nirsevimab and Clesrovimab in Preventing Respiratory Syncytial Virus Lower Respiratory Tract Disease in Infants in the United States: A Modeling Study.Infectious diseases and therapy · 2026Article
- The Impact of Nirsevimab on the Transport of Critically Ill Children.Children (Basel, Switzerland) · 2026Article
- Antibiotic Therapy and Factors Predicting Prolonged Hospitalization Among Children Under Three Years Diagnosed With Respiratory Syncytial Virus-Associated Lower Respiratory Infection.Immunity, inflammation and disease · 2026Article
- Clinical characteristics and prognostic differences of children with acute bronchitis across different age groups.Frontiers in medicine · 2026Article
- Antibiotic overuse in a contemporary cohort of children hospitalized with influenza, RSV, or SARS-CoV-2: a retrospective cohort study.BMC pediatrics · 2025Article
- Mortality Associated With Viral Bronchiolitis in a Pediatric Department: A Retrospective Analysis.Cureus · 2025Article
- Systemic IL-10 and IFN-γ Levels in Respiratory Syncytial Virus- and Rhinovirus-Infected Bulgarian Children with Acute Bronchiolitis and Their Impact on Clinical Manifestation.Pathogens (Basel, Switzerland) · 2025Article
- How to assess the severity of bronchiolitis epidemics? Application of the Moving Epidemic Method in Nouvelle-Aquitaine, France from 2017 to 2023.BMC public health · 2025Article
- Risk factors and circulation pattern of respiratory syncytial virus in children under 2 years in Maputo, Mozambique.International health · 2025Article
- Clinical relevance of bacterial and/or viral coinfection in acute bronchiolitis in an Italian neonatal unit during the 2021-2023 seasons.Frontiers in pediatrics · 2025Article
- Burden of viral respiratory infections in the pediatric intensive care unit: age, virus distribution, and the impact of the COVID-19 pandemic.European journal of pediatrics · 2024Article
- Severe bronchiolitis before and after the COVID-19 pandemic: a retrospective database analysis by the Italian Network of PICU study group (TIPNet).Journal of anesthesia, analgesia and critical care · 2024Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To assess factors associated with outcome in children admitted to paediatric intensive care (PIC) with bronchiolitis. A retrospective study of children admitted to the PICU at St Mary's Hospital, London with bronchiolitis over a 6-year period (2011-2016). All bronchiolitis admissions < 2 years were included. Data collected particularly noted risk factors for severity, demographics, microbiology and outcome. We compared respiratory syncytial virus (RSV) with non-RSV status. Multivariate analysis was performed. Two hundred seventy-four patients were identified. Median age was 60 days (IQR 28-150 days), 63% were male, 90% were invasively ventilated and 42% were previously healthy. Pre-existing co-morbidities were present in 38%. The most frequently isolated pathogens were RSV (60%) and rhinovirus (26%). Co-infection was present in 45%, most commonly with RSV, rhinovirus and bacterial pathogens. Median length of stay (LOS) was 6 days (IQR 4.75-10). Younger age, prematurity, RSV, co-infection and co-morbidity were identified as significant risk factors for prolonged LOS. Six children died. Five of these had documented co-morbidities.
conclusionRSV causes more severe bronchiolitis than other viruses. Nearly half of children admitted to PICU with RSV were previously healthy. Current guidelines for immunoprophylaxis of RSV bronchiolitis should be re-considered. What is Known: • Bronchiolitis is one of the most common reasons for unplanned PICU admission. The most common virus causing bronchiolitis is RSV • Bronchiolitis severe enough to require admission to PICU is associated with frequent morbidity but has low mortality. What is New: • RSV causes more severe bronchiolitis than other viruses. • Nearly half of all children admitted to PICU with RSV were previously healthy.
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