Observational studyDiabetologia2018
Persistence of abnormalities in white matter in children with type 1 diabetes.
Observational study in Diabetologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Long-term Continuous Glucose Monitor Use in Very Young Children With Type 1 Diabetes: One-Year Results From the SENCE Study.Journal of diabetes science and technology · 2023Trial
- A Pilot randomized trial to examine effects of a hybrid closed-loop insulin delivery system on neurodevelopmental and cognitive outcomes in adolescents with type 1 diabetes.Nature communications · 2022Trial
- Executive functioning-related neural processes in emerging adults with type 1 diabetes.Brain imaging and behavior · 2026Article
- White matter microstructure changes across the lifespan: a meta-analysis of longitudinal diffusion MRI studies.bioRxiv : the preprint server for biology · 2025Article
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- The effect of insulin on the central nervous system: insights into neurological complications and management of type 1 diabetes in the pediatric population.Pediatric endocrinology, diabetes, and metabolism · 2025Review
- White matter microstructure damage measured by automated fiber quantification correlates with pain symptoms in lung cancer patients.Brain imaging and behavior · 2024Article
- Safety and Efficacy of Using Advanced Hybrid Closed Loop Off-Label in an Infant Diagnosed with Permanent Neonatal Diabetes Mellitus: A Case Report and a Look to the Future.Children (Basel, Switzerland) · 2024Article
- Diabetes Study of Children of Diverse Ethnicity and Race: Study design.Diabetes/metabolism research and reviews · 2024Observational
- Brain functional and structural changes in diabetic children. How can intellectual development be optimized in type 1 diabetes?Therapeutic advances in chronic disease · 2024Review
- Clinical and Translational Imaging and Sensing of Diabetic Microangiopathy: A Narrative Review.Journal of cardiovascular development and disease · 2023Review
- Exploratory Multisite MR Spectroscopic Imaging Shows White Matter Neuroaxonal Loss Associated with Complications of Type 1 Diabetes in Children.AJNR. American journal of neuroradiology · 2023Article
- Missed meal boluses and poorer glycemic control impact on neurocognitive function may be associated with white matter integrity in adolescents with type 1 diabetes.Frontiers in endocrinology · 2023Article
- ISPAD Clinical Practice Consensus Guidelines 2022: Managing diabetes in preschoolers.Pediatric diabetes · 2022Article
- Peer-support intervention for African American and Latino parents to improve the glycemic control trajectory among school-aged children with type 1 diabetes: A pilot and feasibility protocol.Contemporary clinical trials · 2022Article
- Enhancement of Mitochondrial Function by the Neurogenic Molecule NSI-189 Accompanies Reversal of Peripheral Neuropathy and Memory Impairment in a Rat Model of Type 2 Diabetes.Journal of diabetes research · 2022Article
- Impact of glucose metabolism on the developing brain.Frontiers in endocrinology · 2022Review
- Extreme Glycemic Fluctuations Debilitate NRG1, ErbB Receptors and Olig1 Function: Association with Regeneration, Cognition and Mood Alterations During Diabetes.Molecular neurobiology · 2021Article
- Variation of HbA1c affects cognition and white matter microstructure in healthy, young adults.Molecular psychiatry · 2021Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 1 country.
Funding
Abstract
aims/hypothesisPrior studies suggest white matter growth is reduced and white matter microstructure is altered in the brains of young children with type 1 diabetes when compared with brains of non-diabetic children, due in part to adverse effects of hyperglycaemia. This longitudinal observational study examines whether dysglycaemia alters the developmental trajectory of white matter microstructure over time in young children with type 1 diabetes.
methodsOne hundred and eighteen children, aged 4 to <10 years old with type 1 diabetes and 58 age-matched, non-diabetic children were studied at baseline and 18 months, at five Diabetes Research in Children Network clinical centres. We analysed longitudinal trajectories of white matter using diffusion tensor imaging. Continuous glucose monitoring profiles and HbA
resultsAxial diffusivity was lower in children with diabetes at baseline (p = 0.022) and at 18 months (p = 0.015), indicating that differences in white matter microstructure persist over time in children with diabetes. Within the diabetes group, lower exposure to hyperglycaemia, averaged over the time since diagnosis, was associated with higher fractional anisotropy (p = 0.037). Fractional anisotropy was positively correlated with performance (p < 0.002) and full-scale IQ (p < 0.02). CONCLUSIONS/
interpretationThese results suggest that hyperglycaemia is associated with altered white matter development, which may contribute to the mild cognitive deficits in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.