ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2018
Pedicle screw loosening is correlated to chronic subclinical deep implant infection: a retrospective database analysis.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Unexpected positive culture (UPC) in adults revision spine surgery: a systematic review and meta-analysis of incidence, risk factors, and management.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Pooled it
- A comprehensive review of biomechanical factors influencing pedicle screw fixation strength and the critical role of artificial intelligence.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Low-Dose Vitamin D3 Supplementation: Associations with Vertebral Fragility and Pedicle Screw Loosening.Journal of clinical medicine · 2025Article
- Risk factors for pedicle screw loosening: a comprehensive review.Journal of orthopaedic surgery and research · 2025Review
- The identification of low-pathogenic bacteria on removed spinal implants and implications for antimicrobial prophylaxis.Brain & spine · 2025Article
- The predictive value of endplate morphology and pedicle screw bone quality score on screw loosening after single-level lumbar spinal fusion surgery.Journal of orthopaedic surgery and research · 2024Article
- An Extended Follow-up of Spinal Instrumentation Rescue with Cement Augmentation.AJNR. American journal of neuroradiology · 2024Article
- Explantation of Pedicle Screws: When, Why, and How?Cureus · 2024Review
- Synthesis and evaluation of a novel vancomycin-infused, biomimetic bone graft using a rat model of spinal implant-associated infection.North American Spine Society journal · 2024Article
- Increased Risk of New-Onset Rheumatoid Arthritis Among Osteoarthritis Patients Received Total Knee Arthroplasty: a global federated health network analysis.International journal of medical sciences · 2024Article
- A novel rodent model of chronic spinal implant-associated infection.The spine journal : official journal of the North American Spine Society · 2023Article
- Article
- A prospective study to identify preoperative serum parameters for spinal implant infection detected by sonication fluid culture.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Article
- Evaluating Screw Stability After Pedicle Screw Fixation With PEEK Rods.Global spine journal · 2023Article
- Early fusion outcome after surgical treatment of single-level and multi-level pyogenic spondylodiscitis: experience at a level 1 center for spinal surgery-a single center cohort study.Journal of orthopaedic surgery and research · 2023Article
- SPECT/CT Use as an Indicator of Low-Grade Infection in the Spine: Report of Two Cases.The archives of bone and joint surgery · 2023Article
- Spinal Surgery Site Infection Leading to Implant Loosening Is Influenced by the Number of Prior Operations.Global spine journal · 2022Article
- Improved fixation stability for repairing pedicle screw loosening using a modified cement filling technique in porcine vertebrae.Scientific reports · 2022Article
- Breast Implant-Associated Immunological Disorders.Journal of immunology research · 2022Review
- Revision pedicle screws with impaction bone grafting: a case series.Journal of spine surgery (Hong Kong) · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSpinal fusion is used for treatment of spinal deformities, degeneration, infection, malignancy, and trauma. Reduction of motion enables osseous fusion and permanent stabilization of segments, compromised by loosening of the pedicle screws (PS). Deep implant infection, biomechanical, and chemical mechanisms are suspected reasons for loosening of PS. Study objective was to investigate the frequency and impact of deep implant infection on PS loosening.
methodsIntraoperative infection screening from wound and explanted material sonication was performed during revision surgeries following dorsal stabilization. Case history events and factors, which might promote implant infections, were included in this retrospective survey.
results110 cases of spinal metal explantation were included. In 29.1% of revision cases, infection screening identified a germ, most commonly Staphylococcus (53.1%) and Propionibacterium (40.6%) genus. Patients screened positive had a significant higher number of previous spinal operations and radiologic loosening of screws. Patients revised for adjacent segment failure had a significantly lower rate of positive infection screening than patients revised for directly implant associated reasons. Removal of implants that revealed positive screening effected significant pain relief.
conclusionsChronic implant infection seems to play a role in PS loosening and ongoing pain, causing revision surgery after spinal fusion. Screw loosening and multiple prior spinal operations should be suspicious for implant infection after spinal fusion when it comes to revision surgery. These slides can be retrieved under Electronic Supplementary Material.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.