ArticleCurrent genetics2018
Comparison of the paralogous transcription factors AraR and XlnR in Aspergillus oryzae.
Article in Current genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- AmXlnR, a transcription factor involved in xylan degradation and pentose catabolism, enhances pullulan production from xylose inSynthetic and systems biotechnology · 2026Article
- Dissecting the complex regulation of pentose utilization inCurrent research in microbial sciences · 2025Article
- Regulation of nutrient utilization in filamentous fungi.Applied microbiology and biotechnology · 2023Review
- Novel pentose-regulated promoter ofBiotechnology reports (Amsterdam, Netherlands) · 2022Article
- The Transcription FactorFrontiers in microbiology · 2022Article
- CreA-mediated repression of gene expression occurs at low monosaccharide levels during fungal plant biomass conversion in a time and substrate dependent manner.Cell surface (Amsterdam, Netherlands) · 2021Article
- Blocking utilization of major plant biomass polysaccharides leads Aspergillus niger towards utilization of minor components.Microbial biotechnology · 2021Article
- Characterization of d-xylose reductase, XyrB, fromBiotechnology reports (Amsterdam, Netherlands) · 2021Article
- Induction and Repression of Hydrolase Genes inFrontiers in microbiology · 2021Review
- The role of the VosA-repressed dnjA gene in development and metabolism in Aspergillus species.Current genetics · 2020Article
- Studies of Cellulose and Starch Utilization and the Regulatory Mechanisms of Related Enzymes in Fungi.Polymers · 2020Review
- CreA-independent carbon catabolite repression of cellulase genes by trimeric G-protein and protein kinase A in Aspergillus nidulans.Current genetics · 2019Article
- Mutations in AraR leading to constitutive expression of arabinolytic genes in Aspergillus niger under derepressing conditions [corrected].Applied microbiology and biotechnology · 2019Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
The paralogous transcription factors AraR and XlnR in Aspergillus regulate genes that are involved in degradation of cellulose and hemicellulose and catabolism of pentose. AraR and XlnR target the same genes for pentose catabolism but target different genes encoding enzymes for polysaccharide degradation. To uncover the relationship between these paralogous transcription factors, we examined their contribution to regulation of the PCP genes and compared their preferred recognition sequences. Both AraR and XlnR are involved in induction of all the pentose catabolic genes in A. oryzae except larA encoding L-arabinose reductase, which was regulated by AraR but not by XlnR. DNA-binding studies revealed that the recognition sequences of AraR and XlnR also differ only slightly; AraR prefers CGGDTAAW, while XlnR prefers CGGNTAAW. All the pentose catabolic genes possess at least one recognition site to which both AraR and XlnR can bind. Cooperative binding by the factors was not observed. Instead, they competed to bind to the shared sites. XlnR bound to the recognition sites mentioned above as a monomer, but bound to the sequence TTAGSCTAA on the xylanase promoters as a dimer. Consequently, AraR and XlnR have significantly similar, but not the same, DNA-binding properties. Such a slight difference in these paralogous transcription factors may lead to complex outputs in enzyme production depending on the concentrations of coexisting inducer molecules in the natural environment.
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