ArticleScientific reports2018
On the use of Parylene C polymer as substrate for peripheral nerve electrodes.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics.Frontiers in bioengineering and biotechnology · 2021Pooled it
- Electrochemical Evaluation of Polymer-Based Microelectrode Arrays: Analytical Performance on Oxygen and Hydrogen Peroxide.Sensors (Basel, Switzerland) · 2026Article
- Tantalum Interconnect Metallization for Thin-Film Neural Interface Devices.Micromachines · 2026Article
- Wireless nonresonant stimulation of neurons on a magnetoelectric film surface.Science advances · 2025Article
- Ultra-Sensitive Wireless Capacitive Nanocomposite-Based Pressure Sensors for Health Monitoring.Advanced materials technologies · 2025Article
- Wireless, battery-free, remote photoactivation of caged-morphine for photopharmacological pain modulation without side effects.Biosensors & bioelectronics · 2025Article
- Covalent Binding of Dexamethasone to Polyimide Improves Biocompatibility of Neural Implantable Devices.Advanced healthcare materials · 2025Article
- Article
- Engineered Graphene Material Improves the Performance of Intraneural Peripheral Nerve Electrodes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Recent Progress in Flexible and Wearable All Organic Photoplethysmography Sensors for SpOAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Beyond Tissue replacement: The Emerging role of smart implants in healthcare.Materials today. Bio · 2023Review
- Wireless and battery-free technologies for neuroengineering.Nature biomedical engineering · 2023Review
- Immunohistological responses in mice implanted with Parylene HT - ITO ECoG devices.Frontiers in neuroscience · 2023Article
- In Vivo Penetrating Microelectrodes for Brain Electrophysiology.Sensors (Basel, Switzerland) · 2022Review
- X-Ray Markers for Thin Film Implants.Advanced healthcare materials · 2022Article
- Spatio-temporal feature extraction in sensory electroneurographic signals.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022Article
- Flexible and Stretchable Bioelectronics.Materials (Basel, Switzerland) · 2022Review
- The extended effect of adsorbed damage-associated molecular patterns and Toll-like receptor 2 signaling on macrophage-material interactions.Frontiers in bioengineering and biotechnology · 2022Article
- Sensory feedback for limb prostheses in amputees.Nature materials · 2021Review
- POEMS (POLYMERIC OPTO-ELECTRO-MECHANICAL SYSTEMS) FOR ADVANCED NEURAL INTERFACES.Materials letters · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parylene C is a highly flexible polymer used in several biomedical implants. Since previous studies have reported valuable biocompatible and manufacturing characteristics for brain and intraneural implants, we tested its suitability as a substrate for peripheral nerve electrodes. We evaluated 1-year-aged in vitro samples, where no chemical differences were observed and only a slight deviation on Young's modulus was found. The foreign body reaction (FBR) to longitudinal Parylene C devices implanted in the rat sciatic nerve for 8 months was characterized. After 2 weeks, a capsule was formed around the device, which continued increasing up to 16 and 32 weeks. Histological analyses revealed two cell types implicated in the FBR: macrophages, in contact with the device, and fibroblasts, localized in the outermost zone after 8 weeks. Molecular analysis of implanted nerves comparing Parylene C and polyimide devices revealed a peak of inflammatory cytokines after 1 day of implant, returning to low levels thereafter. Only an increase of CCL2 and CCL3 was found at chronic time-points for both materials. Although no molecular differences in the FBR to both polymers were found, the thick tissue capsule formed around Parylene C puts some concern on its use as a scaffold for intraneural electrodes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.