ArticleScientific reports2018
Metabolomics and pathway analyses to characterize metabolic alterations in pregnant dairy cows on D 17 and D 45 after AI.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 33 citations in OpenAlex.
- Urinary GC-MS metabolomics reveals pregnancy-associated metabolic reprogramming and biomarkers in buffaloes.BMC veterinary research · 2026Article
- Changes in feeding behavior, milk yield, serum indexes, and metabolites of dairy cows in three weeks postpartum.Scientific reports · 2025Article
- Identification of candidate blood biomarkers through metabolomics analysis in bovine superovulation.Frontiers in veterinary science · 2025Article
- Discovery of new quaternized norharmane dimers as potential anti-MRSA agents.Journal of advanced research · 2024Article
- Combining the Vaginal Microbiome and Serum Metabolome to Screen for Potential Biomarkers of Early Pregnancy in Cows.Metabolites · 2024Article
- Molecular docking, molecular dynamics simulations and binding free energy studies of interactions between Mycobacterium tuberculosis Pks13, PknG and bioactive constituents of extremophilic bacteria.Scientific reports · 2024Article
- miRNA-protein-metabolite interaction network reveals the regulatory network and players of pregnancy regulation in dairy cows.Frontiers in cell and developmental biology · 2024Review
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- Blood Metabolites and Faecal Microbial Communities in Nonpregnant and Early Gestation Ewes in Highly Cold Areas.Biology · 2023Article
- Untargeted Metabolomics for Unraveling the Metabolic Changes in Planktonic and Sessile Cells ofAntibiotics (Basel, Switzerland) · 2023Article
- Study on the Mechanism of Jiaotai Pill Intervention on Insomnia Animal Model Based on Gut Microbiome and Metabolomics.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Exploration of urinary metabolite dynamicity for early detection of pregnancy in water buffaloes.Scientific reports · 2022Article
- Untargeted Metabolomics Reveals the Effect of Selective Breeding on the Quality of Chicken Meat.Metabolites · 2022Article
- Pathway analysis in metabolomics: Recommendations for the use of over-representation analysis.PLoS computational biology · 2021Article
- The Investigation of Metabonomic Pathways of Serum of Iranian Women with Recurrent Miscarriage UsingBioMed research international · 2021Article
- Assessing Dynamic Changes of Taste-Related Primary Metabolism During Ripening of Durian Pulp Using Metabolomic and Transcriptomic Analyses.Frontiers in plant science · 2021Article
- Identification of disordered metabolic networks in postpartum dairy cows with left displacement of the abomasum through integrated metabolomics and pathway analyses.The Journal of veterinary medical science · 2020Article
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- Metabolomics Analyses in High-Low Feed Efficient Dairy Cows Reveal Novel Biochemical Mechanisms and Predictive Biomarkers.Metabolites · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nutrient flow to the embryo and placenta is crucial for proper development and growth during pregnancy. In this study, a metabonomic analysis was undertaken to better understand global changes in pregnant dairy cows on D 17 and D 45 after timed artificial insemination (AI). Metabolic changes in the blood plasma of pregnant dairy cows were investigated using HPLC-MS and a multivariate statistical analysis. Changes in metabolic networks were established using the MetPA method. Alterations in six metabolic pathways were found on D 17 and D 45, including variations in the level of alpha-linolenic acid metabolism, glycerophospholipid metabolism, pentose and glucuronate interconversions, glycerolipid metabolism, folate biosynthesis, and tyrosine metabolism. In addition to these pathways, 9 metabolic pathways were markedly altered on D 45. These pathways included changes in the one-carbon pool caused by folate; phenylalanine, tyrosine and tryptophan biosynthesis; thiamine metabolism; pantothenate and CoA biosynthesis; purine metabolism; inositol phosphate metabolism; amino sugar and nucleotide sugar metabolism; pentose phosphate; and the TCA pathway. The combination of metabonomics and network methods used in this study generated rich biochemical insight into possible biological modules related to early pregnancy in dairy cows.
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