Evidence map›Paper›PMID 29654208›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

A Nonpyroptotic IFN-γ-Triggered Cell Death Mechanism in Nonphagocytic Cells Promotes

Justin P Ingram, Sarah Tursi, Ting Zhang, Wei Guo, Chaoran Yin, Meghan A Wynosky-Dolfi, Joris van der Heijden, Kathy Q Cai, Masahiro Yamamoto, B Brett Finlay and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Type I interferon remodels lysosome function and modifies intestinal epithelial defense.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  8. Article
  9. Cell death in the gut epithelium and implications for chronic inflammation.Nature reviews. Gastroenterology & hepatology · 2020
    Review
  10. Article
  11. HumanClinical & translational immunology · 2020
    Article
  12. Cancers · 2019
    Article
  13. Review
  14. IL-1β PromotesFrontiers in immunology · 2019
    Article
  15. ProbioticFrontiers in microbiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 4 countries.

Justin P IngramBlood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA 19111.
Sarah TursiDepartment of Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140.
Ting ZhangBlood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA 19111.
Wei GuoCancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA 19111.
Chaoran YinBlood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA 19111.
Meghan A Wynosky-DolfiDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104.
Joris van der HeijdenMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T1Z4, Canada.
Kathy Q CaiCancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111; and.
Masahiro YamamotoDepartment of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University Suita, Osaka 565-0871, Japan.
B Brett FinlayMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T1Z4, Canada.
Igor E BrodskyDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104.ORCID 0000-0001-7970-872X
Sergei I GrivennikovCancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA 19111.
Çagla TükelDepartment of Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140.ORCID 0000-0001-7073-0226
Siddharth BalachandranBlood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA 19111; Siddharth.balachandran@fccc.edu.
Fox Chase Cancer Center · USTemple University · USUniversity of British Columbia · CAUniversity of Pennsylvania · USThe University of Osaka · JP

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Margaret von Mehren · 1985 to 2026
$138.8M
Mechanism, Function, and Exploitation of Influenza A Virus-Activated Cell DeathR01AI135025 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI BALACHANDRAN, SIDDHARTH · 2017 to 2025
$6.8M
RIP1/3 Kinases as New Targets in Malignant MesotheliomaR01CA190542 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI BALACHANDRAN, SIDDHARTH, TESTA, JOSEPH R. · 2015 to 2019
$2.1M
Interferon Activated Necroptosis as a New Therapeutic Avenue for Kidney CancerR01CA168621 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI BALACHANDRAN, SIDDHARTH · 2014 to 2018
$1.9M
The Role of Interleukin 23 In Colitis Associated CancerR00DK088589 · NIDDK · RESEARCH INST OF FOX CHASE CAN CTR · PI GRIVENNIKOV, SERGEI I · 2013 to 2015
$728k
Control of interferon-activated necrosis by a virus-triggered FADD checkpointR21AI113469 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI BALACHANDRAN, SIDDHARTH · 2014 to 2015
$491k
NCI NIH HHS P30 CA006927NCI NIH HHS R01 CA168621NCI NIH HHS R01 CA190542NIAID NIH HHS R01 AI135025NIAID NIH HHS R21 AI113469NIDDK NIH HHS R00 DK088589
6 · The paper itself

Abstract

The cytokine IFN-γ has well-established antibacterial properties against the bacterium

Indexed as

3T3 CellsAnimalsCell DeathCell LineCytosolEpithelial CellsFibroblastsHumansInflammationInterferon-gammaInterferon Regulatory Factor-1IntestinesMicePhagocytesPyroptosisSalmonella entericaInterferon-gammaInterferon Regulatory Factor-1STAT1 Transcription Factor

Identifiers

PMID29654208
PMCPMC6034694
OpenAlexW2798220540

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.