Evidence map›Paper›PMID 29654191›Full record

ArticleJournal of the American Heart Association2018

Predictors of Mortality and Symptomatic Outcome of Patients With Low-Flow Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement.

Norman Mangner, Georg Stachel, Felix Woitek, Stephan Haussig, Florian Schlotter, Robert Höllriegel, Jennifer Adam, Anna Lindner, Friedrich W Mohr, Gerhard Schuler and 6 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Patients with paradoxical low-flow, low-gradient aortic stenosis gain the least benefit from TAVI among all hemodynamic subtypes.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Article
  6. Observational
  7. Early Stroke Volume Variation After Transcatheter or Surgical Aortic Valve Replacement Predicts Clinical Outcomes in Low-Flow Aortic Stenosis.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025
    Observational
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. ABCDEG Stress Echocardiography in Aortic Stenosis.Diagnostics (Basel, Switzerland) · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Norman MangnerHeart Center Leipzig-University Hospital, Leipzig, Germany norman.mangner@med.uni-leipzig.de.
Georg StachelHeart Center Leipzig-University Hospital, Leipzig, Germany.
Felix WoitekHeart Center Leipzig-University Hospital, Leipzig, Germany.
Stephan HaussigDepartment of Internal Medicine and Cardiology, Heart Center Dresden, Technische Universität Dresden, Dresden, Germany.
Florian SchlotterHeart Center Leipzig-University Hospital, Leipzig, Germany.
Robert HöllriegelDepartment of Internal Medicine and Cardiology, Heart Center Dresden, Technische Universität Dresden, Dresden, Germany.
Jennifer AdamHeart Center Leipzig-University Hospital, Leipzig, Germany.
Anna LindnerHeart Center Leipzig-University Hospital, Leipzig, Germany.
Friedrich W MohrLeipzig Heart Institute, Leipzig, Germany.
Gerhard SchulerHeart Center Leipzig-University Hospital, Leipzig, Germany.
Philipp KieferDepartment of Cardiac Surgery, Heart Center Leipzig, University of Leipzig, Leipzig, Germany.
Sergey LeontyevDepartment of Cardiac Surgery, Heart Center Leipzig, University of Leipzig, Leipzig, Germany.
Michael A BorgerDepartment of Cardiac Surgery, Heart Center Leipzig, University of Leipzig, Leipzig, Germany.
Holger ThieleHeart Center Leipzig-University Hospital, Leipzig, Germany.
David HolzheyDepartment of Cardiac Surgery, Heart Center Leipzig, University of Leipzig, Leipzig, Germany.
Axel LinkeDepartment of Internal Medicine and Cardiology, Heart Center Dresden, Technische Universität Dresden, Dresden, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImpaired left ventricular (LV) ejection fraction is a common finding in patients with aortic stenosis and serves as a predictor of morbidity and mortality after transcatheter aortic valve replacement. However, conflicting data on the most accurate measure for LV function exist. We wanted to examine the impact of LV ejection fraction, mean pressure gradient, and stroke volume index on the outcome of patients treated by transcatheter aortic valve replacement. METHODS AND

resultsPatients treated by transcatheter aortic valve replacement were primarily separated into normal flow (NF; stroke volume index >35 mL/m

conclusionsLF is a common finding within the aortic stenosis population and, in contrast to LV ejection fraction or mean pressure gradient, an independent predictor of all-cause and cardiovascular mortality. Despite increased long-term mortality, high procedural success and excellent functional improvement support transcatheter aortic valve replacement in patients with LF severe aortic stenosis.

Indexed as

AgedAged, 80 and overAortic ValveAortic Valve StenosisEchocardiographyFemaleFollow-Up StudiesGermanyHeart VentriclesHumansMaleRetrospective StudiesSeverity of Illness IndexStroke VolumeSurvival RateTime Factorsaortic stenosislow flowoutcometranscatheter aortic valve implantationtranscatheter aortic valve replacement

Identifiers

PMID29654191
PMCPMC6015421

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.