ArticleCirculation. Arrhythmia and electrophysiology2018
Oxidized CaMKII (Ca
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Article in Circulation. Arrhythmia and electrophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
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Who cites it
39 citing papers in PubMed, 49 citations in OpenAlex.
- Role of NADPH oxidase 2-derived reactive oxygen species in cardiac electrophysiological disorders.Channels (Austin, Tex.) · 2026Review
- Iron, Copper, and Zinc Dyshomeostasis in Cardiovascular and Cerebrovascular Diseases: Redox Mechanisms, Evidence Levels, and Translational Prospects.International journal of molecular sciences · 2026Review
- Exploring the role of CaMKII in exercise-induced cardioprotection.Human cell · 2026Review
- Mitochondrial UQCRC2 as a Redox-Regulatory Node in Metabolic and Cardiometabolic Diseases.Antioxidants (Basel, Switzerland) · 2026Review
- Mutation of a single cysteine in CaMKIIδ protects the heart from ischemia-reperfusion Injury.bioRxiv : the preprint server for biology · 2026Article
- Review
- The sodium/glucose cotransporter 2 inhibitor empagliflozin is a pharmacological chaperone of cardiac NaAmerican journal of physiology. Heart and circulatory physiology · 2025Article
- Immune cells and arrhythmias.Cardiovascular research · 2025Review
- Schisandrin B regulates the SIRT1/PI3K/Akt signaling pathway to ameliorate Ang II-infused cardiac fibrosis.Iranian journal of basic medical sciences · 2025Article
- Conduction defects and arrhythmias inFrontiers in physiology · 2025Article
- Right ventricular preload and afterload challenge induces contractile dysfunction and arrhythmia in isolated hearts of dystrophin-deficient male mice.Physiological reports · 2024Article
- MicroRNA-1 Deficiency Is a Primary Etiological Factor Disrupting Cardiac Contractility and Electrophysiological Homeostasis.Circulation. Arrhythmia and electrophysiology · 2024Article
- Corilagin inhibits angiotensin II-induced atrial fibrosis and fibrillation in mice through the PI3K-Akt pathway.Iranian journal of basic medical sciences · 2024Article
- Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 1.Molecular therapy. Nucleic acids · 2023Article
- Calcium handling dysfunction and cardiac damage following acute ventricular preload challenge in the dystrophin-deficient mouse heart.American journal of physiology. Heart and circulatory physiology · 2023Article
- Genome Editing and Cardiac Arrhythmias.Cells · 2023Review
- CaMKII as a Therapeutic Target in Cardiovascular Disease.Annual review of pharmacology and toxicology · 2023Review
- Advanced glycation end products modulate electrophysiological remodeling of right ventricular outflow tract cardiomyocytes: A novel target for diabetes-related ventricular arrhythmogenesis.Physiological reports · 2022Article
- A microtubule-connexin-43 regulatory link suppresses arrhythmias and cardiac fibrosis in Duchenne muscular dystrophy mice.American journal of physiology. Heart and circulatory physiology · 2022Article
- The role of junctophilin proteins in cellular function.Physiological reviews · 2022Review
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Authors and funding
11 authors at 1 institution in 1 country.
Qiongling WangDepartment of Molecular Physiology and Biophysics (Q.W., A.P.Q., S.C., J.R., D.Y.C., D.B., N.L., G.W., G.G.R., X.H.T.W.), Department of Medicine (Cardiology) (N.L., X.H.T.W.), Department of Pediatrics (Cardiology) (X.H.T.W.), and Center for Space Medicine (X.H.T.W.), Baylor College of Medicine, Houston, TX. Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.Y.C.). Duke University School of Medicine, Durham, NC (D.B.). Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD (M.E.A.).
Ann P QuickDepartment of Molecular Physiology and Biophysics (Q.W., A.P.Q., S.C., J.R., D.Y.C., D.B., N.L., G.W., G.G.R., X.H.T.W.), Department of Medicine (Cardiology) (N.L., X.H.T.W.), Department of Pediatrics (Cardiology) (X.H.T.W.), and Center for Space Medicine (X.H.T.W.), Baylor College of Medicine, Houston, TX. Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.Y.C.). Duke University School of Medicine, Durham, NC (D.B.). Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD (M.E.A.).
Shuyi CaoDepartment of Molecular Physiology and Biophysics (Q.W., A.P.Q., S.C., J.R., D.Y.C., D.B., N.L., G.W., G.G.R., X.H.T.W.), Department of Medicine (Cardiology) (N.L., X.H.T.W.), Department of Pediatrics (Cardiology) (X.H.T.W.), and Center for Space Medicine (X.H.T.W.), Baylor College of Medicine, Houston, TX. Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.Y.C.). Duke University School of Medicine, Durham, NC (D.B.). Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD (M.E.A.).
Julia ReynoldsDepartment of Molecular Physiology and Biophysics (Q.W., A.P.Q., S.C., J.R., D.Y.C., D.B., N.L., G.W., G.G.R., X.H.T.W.), Department of Medicine (Cardiology) (N.L., X.H.T.W.), Department of Pediatrics (Cardiology) (X.H.T.W.), and Center for Space Medicine (X.H.T.W.), Baylor College of Medicine, Houston, TX. Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.Y.C.). Duke University School of Medicine, Durham, NC (D.B.). Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD (M.E.A.).
David Y ChiangDepartment of Molecular Physiology and Biophysics (Q.W., A.P.Q., S.C., J.R., D.Y.C., D.B., N.L., G.W., G.G.R., X.H.T.W.), Department of Medicine (Cardiology) (N.L., X.H.T.W.), Department of Pediatrics (Cardiology) (X.H.T.W.), and Center for Space Medicine (X.H.T.W.), Baylor College of Medicine, Houston, TX. Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.Y.C.). Duke University School of Medicine, Durham, NC (D.B.). Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD (M.E.A.).
David BeaversDepartment of Molecular Physiology and Biophysics (Q.W., A.P.Q., S.C., J.R., D.Y.C., D.B., N.L., G.W., G.G.R., X.H.T.W.), Department of Medicine (Cardiology) (N.L., X.H.T.W.), Department of Pediatrics (Cardiology) (X.H.T.W.), and Center for Space Medicine (X.H.T.W.), Baylor College of Medicine, Houston, TX. Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.Y.C.). Duke University School of Medicine, Durham, NC (D.B.). Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD (M.E.A.).
Na LiDepartment of Molecular Physiology and Biophysics (Q.W., A.P.Q., S.C., J.R., D.Y.C., D.B., N.L., G.W., G.G.R., X.H.T.W.), Department of Medicine (Cardiology) (N.L., X.H.T.W.), Department of Pediatrics (Cardiology) (X.H.T.W.), and Center for Space Medicine (X.H.T.W.), Baylor College of Medicine, Houston, TX. Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.Y.C.). Duke University School of Medicine, Durham, NC (D.B.). Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD (M.E.A.).
Guoliang WangDepartment of Molecular Physiology and Biophysics (Q.W., A.P.Q., S.C., J.R., D.Y.C., D.B., N.L., G.W., G.G.R., X.H.T.W.), Department of Medicine (Cardiology) (N.L., X.H.T.W.), Department of Pediatrics (Cardiology) (X.H.T.W.), and Center for Space Medicine (X.H.T.W.), Baylor College of Medicine, Houston, TX. Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.Y.C.). Duke University School of Medicine, Durham, NC (D.B.). Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD (M.E.A.).
George G RodneyDepartment of Molecular Physiology and Biophysics (Q.W., A.P.Q., S.C., J.R., D.Y.C., D.B., N.L., G.W., G.G.R., X.H.T.W.), Department of Medicine (Cardiology) (N.L., X.H.T.W.), Department of Pediatrics (Cardiology) (X.H.T.W.), and Center for Space Medicine (X.H.T.W.), Baylor College of Medicine, Houston, TX. Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.Y.C.). Duke University School of Medicine, Durham, NC (D.B.). Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD (M.E.A.).
Mark E AndersonDepartment of Molecular Physiology and Biophysics (Q.W., A.P.Q., S.C., J.R., D.Y.C., D.B., N.L., G.W., G.G.R., X.H.T.W.), Department of Medicine (Cardiology) (N.L., X.H.T.W.), Department of Pediatrics (Cardiology) (X.H.T.W.), and Center for Space Medicine (X.H.T.W.), Baylor College of Medicine, Houston, TX. Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.Y.C.). Duke University School of Medicine, Durham, NC (D.B.). Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD (M.E.A.).
Xander H T WehrensDepartment of Molecular Physiology and Biophysics (Q.W., A.P.Q., S.C., J.R., D.Y.C., D.B., N.L., G.W., G.G.R., X.H.T.W.), Department of Medicine (Cardiology) (N.L., X.H.T.W.), Department of Pediatrics (Cardiology) (X.H.T.W.), and Center for Space Medicine (X.H.T.W.), Baylor College of Medicine, Houston, TX. Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.Y.C.). Duke University School of Medicine, Durham, NC (D.B.). Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD (M.E.A.). wehrens@bcm.edu.
Johns Hopkins University · US
Funding
Basis of Muscle Dysfunction in Malignant Hyperthermia & Central Core DiseaseR01AR053349 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI DIRKSEN, ROBERT T, HAMILTON, SUSAN L · 2006 to 2020
$8.0MRyanodine receptor regulation in post-operative atrial fibrillationR01HL089598 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2007 to 2022
$6.5MThe Role of Inflammasome in the Pathogenesis of Atrial FibrillationR01HL136389 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Na Li · 2017 to 2026
$5.6MMitochondrial Calmodulin Kinase II in Physiology and DiseaseR01HL070250 · NHLBI · VANDERBILT UNIVERSITY · PI ANDERSON, MARK E · 2002 to 2017
$5.2MNox2-Calcium Signaling in Skeletal MuscleR01AR061370 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI RODNEY, GEORGE G · 2012 to 2021
$4.1MRegulation of Sarcoplasmic Reticulum Calcium Release in Heart FailureR01HL091947 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2009 to 2019
$3.2MCaMKII in Sinus Node Physiology and DiseaseR01HL096652 · NHLBI · UNIVERSITY OF IOWA · PI ANDERSON, MARK E · 2009 to 2016
$3.0MDetermining the Role of Junctophilin-2 in Cardiac DiseaseR01HL117641 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2014 to 2017
$2.3MDevelopment of novel compounds for the treatment of atrial fibrillationR41HL129570 · NHLBI · ELEX BIOTECH, LLC · PI WEHRENS, XANDER H.T. · 2015 to 2015
$428kNHLBI NIH HHS R01 HL070250NHLBI NIH HHS R01 HL089598NHLBI NIH HHS R01 HL091947NHLBI NIH HHS R01 HL096652NHLBI NIH HHS R01 HL117641NHLBI NIH HHS R01 HL136389NHLBI NIH HHS R41 HL129570NIAMS NIH HHS R01 AR053349NIAMS NIH HHS R01 AR061370
Abstract
backgroundDuchenne muscular dystrophy patients are prone to ventricular arrhythmias, which may be caused by abnormal calcium (Ca METHODS AND
results5-(6)-Chloromethyl-2,7-dichlorodihydrofluorescein diacetate staining revealed increased reactive oxygen species production in ventricular myocytes isolated from
conclusionsInhibition of reactive oxygen species or ox-CaMKII protects against proarrhythmic intracellular Ca
Indexed as
Action PotentialsAnimalsArrhythmias, CardiacCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium SignalingDisease Models, AnimalHeart RateHeart VentriclesMice, Inbred mdxMice, TransgenicMuscular Dystrophy, DuchenneNADPH Oxidase 2Oxidation-ReductionOxidative StressReactive Oxygen SpeciesCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Cybb protein, mouseNADPH Oxidase 2Reactive Oxygen Speciesaction potentialarrhythmiacalcium/calmodulin-dependent protein kinase IIDuchenne muscular dystrophyreactive oxygen species
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.