Evidence map›Paper›PMID 29654114›Full record

ArticleJournal of lipid research2018

Multimodal imaging approach to monitor browning of adipose tissue in vivo.

Xin Hui Derryn Chan, Ghayathri Balasundaram, Amalina Binte Ebrahim Attia, Julian L Goggi, Boominathan Ramasamy, Weiping Han, Malini Olivo, Shigeki Sugii

Abstract read
In one paragraph

Article in Journal of lipid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Brown Adipose Tissue in Breast Cancer Evaluated by [Molecular imaging and biology · 2020
    Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Bioactive Compounds and Adipocyte Browning Phenomenon.Current issues in molecular biology · 2022
    Review
  7. Quantification of brown adipose tissueQuantitative imaging in medicine and surgery · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. European journal of nuclear medicine and molecular imaging · 2019
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xin Hui Derryn ChanFat Metabolism and Stem Cell Group, Singapore Bio-imaging Consortium, Agency for Science, Technology, and Research (A*STAR), Singapore.
Ghayathri BalasundaramLaboratory of Bio-Optical Imaging, Singapore Bio-imaging Consortium, Agency for Science, Technology, and Research (A*STAR), Singapore.
Amalina Binte Ebrahim AttiaLaboratory of Bio-Optical Imaging, Singapore Bio-imaging Consortium, Agency for Science, Technology, and Research (A*STAR), Singapore.
Julian L GoggiIsotopic Molecular Imaging Group, Singapore Bio-imaging Consortium, Agency for Science, Technology, and Research (A*STAR), Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Boominathan RamasamyIsotopic Molecular Imaging Group, Singapore Bio-imaging Consortium, Agency for Science, Technology, and Research (A*STAR), Singapore.
Weiping HanLaboratory of Metabolic Medicine, Singapore Bio-imaging Consortium, Agency for Science, Technology, and Research (A*STAR), Singapore.
Malini OlivoLaboratory of Bio-Optical Imaging, Singapore Bio-imaging Consortium, Agency for Science, Technology, and Research (A*STAR), Singapore; School of Physics, National University of Ireland Galway, Galway, Ireland.
Shigeki SugiiFat Metabolism and Stem Cell Group, Singapore Bio-imaging Consortium, Agency for Science, Technology, and Research (A*STAR), Singapore; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore. Electronic address: shigeki_sugii@sbic.a-star.edu.sg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The discovery that white adipocytes can undergo a browning process to become metabolically active beige cells has attracted significant interest in the fight against obesity. However, the study of adipose browning has been impeded by a lack of imaging tools that allow longitudinal and noninvasive monitoring of this process in vivo. Here, we report a preclinical imaging approach to detect development of beige adipocytes during adrenergic stimulation. In this approach, we expressed near-infrared fluorescent protein, iRFP720, driven under an uncoupling protein-1 (

Indexed as

Multimodal Imaging3T3-L1 CellsAdipose Tissue, BrownAnimalsBiological TransportCell DifferentiationFluorodeoxyglucose F18Magnetic Resonance ImagingMiceMice, Inbred BALB CPhotoacoustic TechniquesPositron-Emission TomographyFluorodeoxyglucose F18adipocytes/obesitybeige fatbio-optical imagingdiabeteslipidsmetabolic diseasemolecular imagingphotoacoustic imaginguncoupling protein-1

Identifiers

PMID29654114
PMCPMC5983400

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.