ArticleBMJ open2018
Hip fracture incidence and mortality in chronic kidney disease: the GLOMMS-II record linkage cohort study.
Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- The association between chronic kidney disease, falls, and fractures: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Pooled it
- Gait characteristics of CKD patients: a systematic review.BMC nephrology · 2019Pooled it
- An Observational Study of Post-hip Fracture Outcomes in Older Adults with Type 2 Diabetes.Journal of general internal medicine · 2026Article
- Article
- Impact of fluorosis on mineral bone disorders in CKDu populations: a cross-sectional study.BMC nephrology · 2025Article
- Postoperative risk profile in elderly hip fracture patients undergoing chronic hemodialysis based on a nationwide database investigation.Scientific reports · 2025Article
- Chronic comorbidities and risk of 30-day mortality in hip fracture patients- a Danish National patient registry study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- FPG Score: A Rapid Admission-Based Tool for Predicting In-Hospital Mortality in Elderly Hip Fracture Patients.Orthopaedic surgery · 2025Observational
- Effects of chronic kidney disease on complications and mortality after fracture surgery.Perioperative medicine (London, England) · 2025Article
- Adiposity and Mineral Balance in Chronic Kidney Disease.Current osteoporosis reports · 2024Review
- Parathyroidectomy restored bone mineral density in a neglected femoral neck fracture with renal osteodystrophy: A case report.World journal of clinical cases · 2024Article
- Effect of Chronic Kidney Disease on All-Cause Mortality After Hip Fracture Surgery: A Retrospective Cohort Study.Calcified tissue international · 2024Article
- Bilateral Femoral Neck Fractures in a 50-Year-Old Patient with Chronic Kidney Disease.The American journal of case reports · 2024Article
- The Nomogram Model and Factors for the Postoperative Mortality of Elderly Patients with Femoral Neck Fracture Undergoing Artificial Hip Arthroplasty: A Single-Institution 6-Year Experience.Orthopaedic surgery · 2024Article
- Prognostic Factors of Hip Fracture in Elderly: A Systematic Review.International journal of preventive medicine · 2024Review
- The association between dietary inflammation index and bone mineral density: results from the United States National Health and nutrition examination surveys.Renal failure · 2023Article
- Degree of Albuminuria is Associated With Increased Risk of Fragility Fractures Independent of Estimated GFR.Kidney international reports · 2023Article
- Is Follow-up Co-Morbidity Assessment via Laboratory Investigations in Older High Energy Trauma Patients Justified? - A Prospective-Retrospective Study.Malaysian orthopaedic journal · 2023Article
- Single cell cortical bone transcriptomics define novel osteolineage gene sets altered in chronic kidney disease.Frontiers in endocrinology · 2023Article
- Skeletal Muscle Complications in Chronic Kidney Disease.Current osteoporosis reports · 2022Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
Abstract
backgroundIndividuals on renal replacement therapy (RRT) have increased fracture risk, but risk in less advanced chronic kidney disease (CKD) is unclear.
objectiveTo investigate CKD associations with hip fracture incidence and mortality.
designRecord linkage cohort study Grampian Laboratory Outcomes Mortality and Morbidity Study II.
settingSingle health region in Scotland.
participantsAll individuals (≥15 years) with sustained CKD stages 3-5 and those on RRT, and a 20% random sample of those with normal renal function, in the resident population in 2003. OUTCOME MEASURES: Outcomes were (1) incident hip fracture measured with (A) admissions or (B) deaths, with at least 5.5 years follow-up and (2) post-hip fracture mortality. Unadjusted and adjusted, incident rate ratios (IRRs) and mortality rate ratios were calculated using Poisson regression.
resultsOf 39 630 individuals identified in 2003 (41% males, mean age 63.3 years), 19 537 had CKD stages 3-5, 345 were on RRT and 19 748 had normal estimated glomerular filtration rate (eGFR). Hip fracture incidence, measured by admissions, was increased in CKD stages 3-5 (compared with normal eGFR), both overall (adjusted IRR 1.49 (95% CI 1.24 to 1.79)) and for individual CKD stages 3a, 3b and 4. Hip fracture incidence, measured using deaths, was increased in those with CKD stages 3b and 4. Post-hip fracture mortality was only increased in CKD stage 4. There was only a small number of individuals and events for CKD stage 5, resulting in insufficient statistical power.
conclusionHip fracture incidence was higher in CKD stages 3-5 compared with normal eGFR. Post-hip fracture mortality was only increased in CKD stage 4. Reducing hip fracture incidence in CKD through regular fall and fracture risk review should reduce overall deaths after hip fracture in the population.
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