Evidence map›Paper›PMID 29653971›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2018

Safety, Pharmacokinetics, and Dosimetry of a Long-Acting Radiolabeled Somatostatin Analog

Jingjing Zhang, Hao Wang, Orit Jacobson, Yuejuan Cheng, Gang Niu, Fang Li, Chunmei Bai, Zhaohui Zhu, Xiaoyuan Chen

Open access · bronzeAbstract readClinical Trial, Phase I
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 93 citations in OpenAlex.

  1. Application of theranostics in thyroid cancer management.The Journal of clinical endocrinology and metabolism · 2026
    Review
  2. Tailored Reaction Conditions and Automated Radiolabeling of [International journal of molecular sciences · 2025
    Article
  3. Article
  4. Deciphering the Tumor Uptake of Heterobivalent (SSTJournal of medicinal chemistry · 2025
    Article
  5. Preclinical safety and effectiveness of a long-acting somatostatin analogue [European journal of nuclear medicine and molecular imaging · 2025
    Article
  6. Article
  7. Safety, pharmacokinetics, and dosimetry ofActa pharmaceutica Sinica. B · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Determinants of target absorbed dose in radionuclide therapy.Zeitschrift fur medizinische Physik · 2023
    Article
  14. Review
  15. New Biology of Pheochromocytoma and Paraganglioma.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
    Review
  16. Combined Targeted Radiopharmaceutical Therapy and Immune Checkpoint Blockade: From Preclinical Advances to the Clinic.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  17. Article
  18. Deciphering albumin-directed drug delivery by imaging.Advanced drug delivery reviews · 2022
    Review
  19. Albumin Binder-Conjugated Fibroblast Activation Protein Inhibitor Radiopharmaceuticals for Cancer Therapy.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  20. Fatty acid-conjugated radiopharmaceuticals for fibroblast activation protein-targeted radiotherapy.European journal of nuclear medicine and molecular imaging · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Jingjing ZhangDepartment of Nuclear Medicine, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing, China.
Hao WangDepartment of Nuclear Medicine, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing, China.
Orit JacobsonLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland.
Yuejuan ChengOncology Department of Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing, China.
Gang NiuLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland.
Fang LiDepartment of Nuclear Medicine, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing, China.
Chunmei BaiOncology Department of Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing, China.
Zhaohui ZhuDepartment of Nuclear Medicine, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing, China 13611093752@163.com shawn.chen@nih.gov.
Xiaoyuan ChenLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland 13611093752@163.com shawn.chen@nih.gov.
National Institutes of Health · USCapital Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNNational Institute of Biomedical Imaging and Bioengineering · USPeking Union Medical College Hospital · CN

Funding

Laboratory of Molecular Imaging and NanomedicineZIAEB000073 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI CHEN, XIAOYUAN · 2010 to 2020
$32.8M
Molecular Tracer and Imaging Core FacilityZICEB000087 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI LANG, LIXIN · 2017 to 2025
$11.3M
6 · The paper itself

Abstract

Radiolabeled somatostatin analog therapy has become an established treatment method for patients with well to moderately differentiated unresectable or metastatic neuroendocrine tumors (NETs). The most frequently used somatostatin analogs in clinical practice are octreotide and octreotate. However, both peptides showed suboptimal retention within tumors. The aim of this first-in-humans study is to explore the safety and dosimetry of a long-acting radiolabeled somatostatin analog,

Indexed as

AdultCoordination ComplexesEvans BlueFemaleHumansKidneyLutetiumMaleMiddle AgedNeuroendocrine TumorsOctreotideOrganometallic CompoundsPositron Emission Tomography Computed TomographyRadioisotopesRadiopharmaceuticalsRadiotherapy Dosage(177)Lu-DOTA-EB-TATE177Lu-DOTA-octreotateCoordination ComplexesEvans BlueLutetiumLutetium-177lutetium Lu 177 dotatateOctreotideOrganometallic CompoundsRadioisotopesRadiopharmaceuticalsSomatostatinEvans blueneuroendocrine tumor (NET)peptide receptor radionuclide therapy (PRRT)somatostatin receptor (SSTR)TATE

Identifiers

PMID29653971
PMCPMC6225536
OpenAlexW2796636484

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.