Evidence map›Paper›PMID 29653963›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2018

NOX4 Deletion in Male Mice Exacerbates the Effect of Ethanol on Trabecular Bone and Osteoblastogenesis.

James Watt, Alexander W Alund, Casey F Pulliam, Kelly E Mercer, Larry J Suva, Jin-Ran Chen, Martin J J Ronis

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Aging Exacerbates Binge Ethanol-Mediated Bone Toxicity in Mice.Alcohol, clinical & experimental research · 2026
    Article
  2. Review
  3. Review
  4. Making Sense of the Highly Variable Effects of Alcohol on Bone.Clinical reviews in bone and mineral metabolism · 2021
    Article
  5. Article
  6. Article
  7. Article
  8. Skeletal Toxicity of Coplanar Polychlorinated Biphenyl Congener 126 in the Rat Is Aryl Hydrocarbon Receptor Dependent.Toxicological sciences : an official journal of the Society of Toxicology · 2020
    Article
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

James WattDepartment of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana (J.W., C.F.P., M.J.J.R.); Interdisciplinary Biological Sciences Program (A.W.A.) and Department of Pediatrics, Arkansas Children's Nutrition Center (K.E.M., J.-R.C.), University of Arkansas for Medical Sciences, Little Rock, Arkansas; and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (L.J.S.).
Alexander W AlundDepartment of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana (J.W., C.F.P., M.J.J.R.); Interdisciplinary Biological Sciences Program (A.W.A.) and Department of Pediatrics, Arkansas Children's Nutrition Center (K.E.M., J.-R.C.), University of Arkansas for Medical Sciences, Little Rock, Arkansas; and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (L.J.S.).
Casey F PulliamDepartment of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana (J.W., C.F.P., M.J.J.R.); Interdisciplinary Biological Sciences Program (A.W.A.) and Department of Pediatrics, Arkansas Children's Nutrition Center (K.E.M., J.-R.C.), University of Arkansas for Medical Sciences, Little Rock, Arkansas; and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (L.J.S.).
Kelly E MercerDepartment of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana (J.W., C.F.P., M.J.J.R.); Interdisciplinary Biological Sciences Program (A.W.A.) and Department of Pediatrics, Arkansas Children's Nutrition Center (K.E.M., J.-R.C.), University of Arkansas for Medical Sciences, Little Rock, Arkansas; and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (L.J.S.).
Larry J SuvaDepartment of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana (J.W., C.F.P., M.J.J.R.); Interdisciplinary Biological Sciences Program (A.W.A.) and Department of Pediatrics, Arkansas Children's Nutrition Center (K.E.M., J.-R.C.), University of Arkansas for Medical Sciences, Little Rock, Arkansas; and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (L.J.S.).
Jin-Ran ChenDepartment of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana (J.W., C.F.P., M.J.J.R.); Interdisciplinary Biological Sciences Program (A.W.A.) and Department of Pediatrics, Arkansas Children's Nutrition Center (K.E.M., J.-R.C.), University of Arkansas for Medical Sciences, Little Rock, Arkansas; and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (L.J.S.).
Martin J J RonisDepartment of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana (J.W., C.F.P., M.J.J.R.); Interdisciplinary Biological Sciences Program (A.W.A.) and Department of Pediatrics, Arkansas Children's Nutrition Center (K.E.M., J.-R.C.), University of Arkansas for Medical Sciences, Little Rock, Arkansas; and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (L.J.S.) mronis@lsuhsc.edu.
Louisiana State University Health Sciences Center New Orleans · USArkansas Children's Nutrition Center · USTexas A&M University · USUniversity of Arkansas for Medical Sciences · US

Funding

The role of oxidative stress in alcohol-induced osteopeniaR37AA018282 · NIAAA · LSU HEALTH SCIENCES CENTER · PI RONIS, MARTIN J J · 2016 to 2025
$4.7M
Systems Pharmacology and Toxicology Training ProgramT32GM106999 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI PRATHER, PAUL L · 2013 to 2022
$1.4M
NIAAA NIH HHS R37 AA018282NIGMS NIH HHS T32 GM106999
6 · The paper itself

Abstract

Chronic alcohol consumption increases bone resorption and decreases bone formation. A major component of ethanol (EtOH) pathology in bone is the generation of excess reactive oxygen species (ROS). The ROS-generating NADPH oxidase-4 (NOX4) is proposed to drive much of the EtOH-induced suppression of bone formation. Here, 13-week-old male wild-type (WT) and NOX4

Indexed as

Gene DeletionAnimalsCancellous BoneEthanolMaleMiceMice, Inbred C57BLNADPH Oxidase 4OsteoblastsOsteogenesisX-Ray MicrotomographyEthanolNADPH Oxidase 4

Identifiers

PMID29653963
PMCPMC5988025
OpenAlexW2796711308

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.