Evidence map›Paper›PMID 29653941›Full record

GuidelineGut2018

Guidelines for the investigation of chronic diarrhoea in adults: British Society of Gastroenterology, 3rd edition.

Ramesh P Arasaradnam, Steven Brown, Alastair Forbes, Mark R Fox, Pali Hungin, Lawrence Kelman, Giles Major, Michelle O'Connor, Dave S Sanders, Rakesh Sinha and 3 more

2 registry-linked trialsAbstract readPractice Guideline
In one paragraph

Guideline in Gut, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 138 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06839586 phase1 / phase2active not recruitingnot on this mapstarted 2025, after this paper: background citation

The Efficacy and Safety of CMTS4520 for Chronic Diarrhoea in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.

TypeinterventionalSponsorThe Second Hospital of Nanjing Medical UniversityRan2025 to 2030Enrolled100ConditionsDiarrhoeaArmsCMTS4520 (dietary fiber and probiotics), Placebo
NCT06839599 phase1 / phase2not yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Efficacy and Safety of CMTS4520-Assisted Washed Microbiota Transplantation for Chronic Diarrhoea in Adults: a Randomized, Double-Blind, Placebo-Controlled Trial.

TypeinterventionalSponsorThe Second Hospital of Nanjing Medical UniversityRan2025 to 2030Enrolled100ConditionsDiarrheaArmsCMTS4520 (dietary fiber probiotics), Placebo
3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Guideline
  4. Guideline
  5. Effectiveness of diet, psychological, and exercise therapies for the management of bile acid diarrhoea in adults: A systematic review.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2022
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Guideline
  9. Pooled it
  10. Pooled it
  11. Trial
  12. Trial
  13. Trial
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review

78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Ramesh P ArasaradnamUniversity Hospital Coventry, Coventry, UK.
Steven BrownSheffield Teaching Hospitals, Sheffield, UK.
Alastair ForbesNorwich Medical School, University of East Anglia, Norwich, UK.
Mark R FoxUniversity of Zürich, Zürich, Switzerland.
Pali HunginSchool of Medicine, Pharmacy & Health, University of Durham, Durham, UK.
Lawrence KelmanPatient Representative, Secretary BAM Support, Coventry, UK.
Giles MajorNIHR Nottingham Biomedical Research Centre (BRC), Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK.
Michelle O'ConnorPatient Representative, Secretary BAM Support, Coventry, UK.
Dave S SandersSheffield Teaching Hospitals, Sheffield, UK.
Rakesh SinhaDepartment of Radiology, South Warwickshire Hospitals, Warwick, UK.
Stephen Charles SmithDepartment of Clinical Biochemistry, Midlands and NW Bowel Cancer Screening Hub, Rugby, UK.
Paul ThomasDepartment of Gastroenterology, Musgrave Park Hospital, Taunton, UK.
Julian R F WaltersDivision of Digestive Diseases, Imperial College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic diarrhoea is a common problem, hence clear guidance on investigations is required. This is an updated guideline from 2003 for the investigations of chronic diarrhoea commissioned by the Clinical Services and Standards Committee of the British Society of Gastroenterology (BSG). This document has undergone significant revision in content through input by 13 members of the Guideline Development Group (GDG) representing various institutions. The GRADE system was used to appraise the quality of evidence and grading of recommendations.

Indexed as

AdultChronic DiseaseDiarrheaHumansdiarrhoeadiarrhoeal disease

Identifiers

PMID29653941
PMCPMC6204957

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.