Evidence map›Paper›PMID 29653940›Full record

ArticleG3 (Bethesda, Md.)2018

The Atypical Rho GTPase CHW-1 Works with SAX-3/Robo To Mediate Axon Guidance in

Jamie K Alan, Sara K Robinson, Katie L Magsig, Rafael S Demarco, Erik A Lundquist

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. TRP Channels Regulation of Rho GTPases in Brain Context and Diseases.Frontiers in cell and developmental biology · 2020
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jamie K AlanDepartment of Pharmacology and Toxicology; Michigan State University; East Lansing, MI 48824 jamie.alan@hc.msu.edu.ORCID 0000-0002-3781-7693
Sara K RobinsonCollege of Medicine; Central Michigan University; Mount Pleasant, MI 48859.
Katie L MagsigCollege of Medicine; Central Michigan University; Mount Pleasant, MI 48859.ORCID 0000-0002-7898-8536
Rafael S DemarcoDepartment of Molecular Biosciences; University of Kansas; Lawrence, KS 60045.
Erik A LundquistDepartment of Molecular Biosciences; University of Kansas; Lawrence, KS 60045.ORCID 0000-0001-6819-4815
Central Michigan University · USUniversity of Kansas · USMichigan State University · US

Funding

CYTOSKELETAL SIGNALING AND AXON GUIDANCER01NS040945 · NINDS · UNIVERSITY OF KANSAS LAWRENCE · PI LUNDQUIST, ERIK A · 2001 to 2013
$3.3M
NINDS NIH HHS R01 NS040945
6 · The paper itself

Abstract

During development, neuronal cells extend an axon toward their target destination in response to a cue to form a properly functioning nervous system. Rho proteins, Ras-related small GTPases that regulate cytoskeletal organization and dynamics, cell adhesion, and motility, are known to regulate axon guidance. Despite extensive knowledge about canonical Rho proteins (RhoA/Rac1/Cdc42), little is known about the

Indexed as

Axon GuidanceAmino Acid SequenceAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell Cycle ProteinsGTP-Binding ProteinsMotor NeuronsNerve Tissue ProteinsPseudopodiaReceptors, Immunologicrho GTP-Binding ProteinsRoundabout ProteinsCaenorhabditis elegans Proteinscdc-42 protein, C elegansCell Cycle ProteinsCHW-1 protein, C elegansGTP-Binding ProteinsNerve Tissue ProteinsReceptors, Immunologicrho GTP-Binding ProteinsRoundabout Proteinsaxon pathfindingCDC-42CHW-1CRP-1SAX-3/Robo

Identifiers

PMID29653940
PMCPMC5982818
OpenAlexW2795950822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.