ArticleProceedings of the National Academy of Sciences of the United States of America1988
Expression of cellular protooncogenes in the mouse male germ line: a distinctive 2.4-kilobase pim-1 transcript is expressed in haploid postmeiotic cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 98 citations in OpenAlex.
- Role of selenium in spermatogenesis: differential expression of cjun and cfos in tubular cells of mice testis.Molecular and cellular biochemistry · 2006Article
- Cryptic promoter activity in the DNA sequence corresponding to the pim-1 5'-UTR.Nucleic acids research · 2005Article
- Developmental expression of pim kinases suggests functions also outside of the hematopoietic system.Oncogene · 2000Article
- Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis.The Biochemical journal · 1999Article
- Identification and localization of secretin and secretin receptor mRNAs in rat testis.Endocrine · 1995Article
- In vivo analysis of Pim-1 deficiency.Nucleic acids research · 1993Article
- Molecular cloning, nucleotide sequence and expression of a cDNA encoding an intracellular protein tyrosine phosphatase, PTPase-2, from mouse testis and T-cells.Molecular and cellular biochemistry · 1992Article
- Characterization of the testes-specific pim-1 transcript in rat.Nucleic acids research · 1992Article
- The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG.The EMBO journal · 1991Article
- Dissection of the mouse N-ras gene upstream regulatory sequences and identification of the promoter and a negative regulatory element.Molecular and cellular biology · 1991Article
- Genetic mapping of a male germ cell-expressed gene Tpx-2 to mouse chromosome 17.Immunogenetics · 1991Article
- List of cloned mouse genes with unique expression patterns during spermatogenesis.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Article
- The testis-specific transcript (ferT) of the tyrosine kinase FER is expressed during spermatogenesis in a stage-specific manner.Molecular and cellular biology · 1990Article
- Characterization of unr; a gene closely linked to N-ras.Nucleic acids research · 1990Article
- A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis.Molecular and cellular biology · 1990Article
- Murine beta 1,4-galactosyltransferase: both the amounts and structure of the mRNA are regulated during spermatogenesis.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues.American journal of human genetics · 1989Article
- The c-cbl proto-oncogene is preferentially expressed in thymus and testis tissue and encodes a nuclear protein.Journal of virology · 1989Article
- A mouse chromosome 17 gene encodes a testes-specific transcript with unusual properties.Immunogenetics · 1989Article
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5 authors at 1 institution in 1 country.
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Abstract
We report that a 2.4-kilobase (kb) pim-1 transcript is expressed in the germ cells of mouse testis. Analysis of purified populations of spermatogenic cell types indicates that the 2.4-kb transcript is selectively expressed in haploid postmeiotic early spermatids. The evidence for a developmentally regulated expression of pim-1 in haploid spermatids suggests a possible developmental role for this protooncogene product. The 2.4-kb pim-1 transcript present in postmeiotic cells differs in size from the 2.8-kb transcript usually detected in somatic tissues. Similar testis-specific transcripts have been seen for mos and abl genes. These data suggest specificity in transcription or processing of certain genes in haploid male germ cells. We have also analyzed other representative protooncogenes, including examples of protein kinases, the ras family, and the "nuclear" protooncogenes. The results indicate that additional protooncogenes are preferentially expressed in either meiotic pachytene cells or postmeiotic early spermatids. These findings suggest a differential regulation of gene expression in these two developmental stages of germ cells. In particular, analysis of expression of the three members of the ras gene family indicates a distinct temporal differential regulation in the expression of the Harvey, Kirsten, and N-ras genes in these germ cells.
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