ReviewAmerican heart journal2018
Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC).
Abstract readReview
In one paragraph
Review in American heart journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Priorities for Advancing Mental and Social Health Among People Presenting for Care of Musculoskeletal Symptoms : International Consortium for Mental and Social Health in Musculoskeletal Care.Journal of clinical psychology in medical settings · 2023Article
- Pharmacogenetics of Antiplatelet Therapy.Annual review of pharmacology and toxicology · 2023Review
- Polygenic Risk Scores for Cardiovascular Disease: A Scientific Statement From the American Heart Association.Circulation · 2022Review
- Genome-Wide Studies in Ischaemic Stroke: Are Genetics Only Useful for Finding Genes?International journal of molecular sciences · 2022Review
- Genome-Wide Approach to Measure Variant-Based Heritability of Drug Outcome Phenotypes.Clinical pharmacology and therapeutics · 2021Article
- PharmVar GeneFocus: CYP2C19.Clinical pharmacology and therapeutics · 2021Review
- Retrospective Review of Pharmacogenetic Testing at an Academic Children's Hospital.Clinical and translational science · 2021Article
- Genomewide Association Study of Platelet Reactivity and Cardiovascular Response in Patients Treated With Clopidogrel: A Study by the International Clopidogrel Pharmacogenomics Consortium.Clinical pharmacology and therapeutics · 2020Article
- Effect ofGenes · 2020Article
- Pharmacogenomic polygenic response score predicts ischaemic events and cardiovascular mortality in clopidogrel-treated patients.European heart journal. Cardiovascular pharmacotherapy · 2020Article
- Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities.Clinical pharmacology and therapeutics · 2020Article
- Bleeding and Thrombosis With Pediatric Extracorporeal Life Support: A Roadmap for Management, Research, and the Future From the Pediatric Cardiac Intensive Care Society: Part 1.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2019Review
- Implications of genetic variation of common Drug Metabolizing Enzymes and ABC Transporters among the Pakistani Population.Scientific reports · 2019Article
- Pharmacogenomic considerations for antiplatelet agents: the era of precision medicine in stroke prevention and neurointerventional practice.Cold Spring Harbor molecular case studies · 2019Review
- Platelet biology and functions: new concepts and clinical perspectives.Nature reviews. Cardiology · 2019Review
- Essential Characteristics of Pharmacogenomics Study Publications.Clinical pharmacology and therapeutics · 2019Review
- Stratified Approaches to Antiplatelet Therapies Based on Platelet Reactivity Testing.Frontiers in cardiovascular medicine · 2019Review
- Genetic drivers of cerebral blood flow dysfunction in TBI: a speculative synthesis.Nature reviews. Neurology · 2019Review
- The Management of Heavy Menstrual Bleeding After Percutaneous Coronary Intervention in a Woman of Reproductive Age.Frontiers in pharmacology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
48 authors.
Thomas O BergmeijerSt Antonius Center for Platelet Function Research, Department of Cardiology, St Antonius Hospital Nieuwegein, the Netherlands.
Jean-Luc RenyInternal Medicine, Béziers Hospital, France, Geneva Platelet Group, University of Geneva School of Medicine, Department of Internal Medicine, Rehabilitation and Geriatrics, University Hospitals of Geneva, Geneva, Switzerland.
Ruth E PakyzDepartment of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Li GongDepartment of Biomedical Data Science, Stanford University, Stanford, CA, USA.
Joshua P LewisDepartment of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Eun-Young KimDepartment of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, South Korea.
Daniel AradiHeart Center Balatonfüred and Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Israel Fernandez-CadenasStroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mútua Terrassa, Neurovascular Research Laboratory, Valle d'Hebron Hebron Institute of Research, Barcelona, Spain.
Richard B HorensteinDepartment of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Ming Ta Michael LeeGenomic Medicine Institute, Geisinger Health System, Danville, PA, USA.
Ryan M WhaleyDepartment of Biomedical Data Science, Stanford University, Stanford, CA, USA.
Joan MontanerNeurovascular Research Laboratory, Vall d'Hebron Institute of Research, Barcelona, Spain.
Gian Franco GensiniDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
John H CleatorDepartments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Kiyuk ChangCardiovascular Center and Cardiology Division, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Lene HolmvangDepartment of Cardiology and Cardiac Catheterization Laboratory, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Willibald HochholzerUniversity Heart Center Freiburg, Bad Krozingen, Department of Cardiology and Angiology II, Bad Krozingen, Germany.
Dan M RodenDepartments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.
Stefan WinterDr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen, Germany.
Russ B AltmanDepartment of Biomedical Data Science, Stanford University, Stanford, CA, USA; Departments of Bioengineering and Genetics, Stanford University, Stanford, CA, USA; Department of Medicine, Stanford University, Stanford, CA, USA.
Dimitrios AlexopoulosDepartment of Cardiology, Patras University Hospital, Patras, Greece.
Ho-Sook KimDepartment of Pharmacology and Pharmacogenomics Research Center, College of Medicine, Inje University, Busan, South Korea.
Jean-Pierre DéryQuebec Heart and Lung Institute, Québec, Canada.
Meinrad GawazDepartment of Cardiology and Cardiovascular Medicine, University Hospital Tübingen, Tübingen, Germany.
Kevin BlidenInova Center for Thrombosis Research and Drug Development. Inova Heart and Vascular Institute, Falls Church, VA, USA.
Marco ValgimigliDepartment of Cardiology, Swiss Cardiovascular Center Bern, Bern University Hospital, Bern, Switzerland.
Rossella MarcucciDepartment of Experimental and Clinical Medicine, University of Florence, Atherothrombotic Diseases Center, Careggi Hospital, Florence, Italy.
Gianluca CampoCardiology Unit, Azienda Ospedaliera Universitria di Ferrara, Cona (FE) and Maria Cecilia Hospital, GVM Care and Research, Cotignola, (RA), Italy.
Elke SchaeffelerDr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen, Germany.
Nadia P DridiDepartment of Cardiology and Cardiac Catheterization Laboratory, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Ming-Shien WenDivision of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou and School of Medicine, Chang Gung University, Taoyuan City, Taiwan.
Jae Gook ShinDepartment of Pharmacology and Pharmacogenomics Research Center, College of Medicine, Inje University, Busan, South Korea.
Tabassome SimonAPHP, Saint Antoine Hospital, Paris, France.
Pierre FontanaGeneva Platelet Group, University of Geneva School of Medicine, Division of Angiology and Haemostasis, University Hospitals of Geneva, Geneva, Switzerland.
Betti GiustiDepartment of Experimental and Clinical Medicine, University of Florence, Atherothrombotic Diseases Center, Careggi Hospital, Florence, Italy.
Tobias GeislerDepartment of Cardiology and Cardiovascular Medicine, University Hospital Tübingen, Tübingen, Germany.
Michiaki KuboLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.
Dietmar TrenkDepartment of Cardiology and Cardiovascular Medicine, University Hospital Tübingen, Tübingen, Germany.
Jolanta M Siller-MatulaDepartment of Cardiology, Medical University of Vienna, Vienna, Austria.
Jurriën M Ten BergSt Antonius Center for Platelet Function Research, Department of Cardiology, St Antonius Hospital Nieuwegein, the Netherlands.
Paul A GurbelInova Center for Thrombosis Research and Drug Development. Inova Heart and Vascular Institute, Falls Church, VA, USA.
Jean-Sebastien HulotSorbonne Universités, UPMC Univ Paris 06, Institute of Cardiometabolism and Nutrition (ICAN), Pitié-Salpêtrière Hospital, F-75013 Paris, France.
Braxton D MitchellDepartment of Medicine, University of Maryland, Baltimore, MD, USA; Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center, Baltimore, MD.
Matthias SchwabDr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen, Germany; Department of Clinical Pharmacology, University Hospital, Tübingen, Germany.
Marylyn DeRiggi RitchieDepartment of Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA.
Teri E KleinDepartment of Biomedical Data Science, Stanford University, Stanford, CA, USA; Department of Medicine, Stanford University, Stanford, CA, USA.
Alan R ShuldinerDepartment of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: ashuldin@som.umaryland.edu.
ICPC Investigators
Funding
PharmGKB: pharmacogenomics knowledge for precision medicineR24GM061374 · NIGMS · STANFORD UNIVERSITY · PI ALTMAN, RUSS BIAGIO, KLEIN, TERI ELLEN · 2010 to 2018
$25.2MPHARMACOGENOMICS OF ARRHYTHMIA THERAPYU01HL065962 · NHLBI · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2001 to 2009
$24.8MPharmacogenomics of Arrhythmia TherapyU19HL065962 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2010 to 2014
$17.4MPharmacogenomics of Anti-platlet Intervention-2 (PAPI-2) StudyU01HL105198 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI SHULDINER, ALAN R. · 2010 to 2014
$13.6MThe Impact of Carboxylesterase 1 ( CES1 ) in Personalized Antiplalet TherapyR01HL137922 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI LEWIS, JOSHUA PATRICK · 2017 to 2021
$1.9MNHLBI NIH HHS R01 HL137922NHLBI NIH HHS U01 HL065962NHLBI NIH HHS U01 HL105198NHLBI NIH HHS U19 HL065962NIGMS NIH HHS R24 GM061374
Abstract
rationaleThe P2Y STUDY
designBased on the data published on www.clinicaltrials.gov, clopidogrel intervention studies containing genetic and platelet function data were identified for participation. Lead investigators were invited to share DNA samples, platelet function test results, patient characteristics, and cardiovascular outcomes to perform candidate gene and genome-wide studies.
resultsIn total, 17 study sites from 13 countries participate in the ICPC, contributing individual patient data from 8,829 patients. Available adenosine diphosphate-stimulated platelet function tests included vasodilator-stimulated phosphoprotein assay, light transmittance aggregometry, and the VerifyNow P2Y
conclusionThe ICPC aims to identify new loci influencing clopidogrel efficacy by using state-of-the-art genetic approaches in a large cohort of clopidogrel-treated patients to better understand the genetic basis of on-treatment response variability.
Indexed as
Acute Coronary SyndromeClopidogrelGenome-Wide Association StudyMolecular Targeted TherapyReceptors, Purinergic P2Y12AgedFemaleGenetic Association StudiesHumansInternationalityMaleMiddle AgedPharmacogeneticsPrognosisRisk AssessmentSurvival RateClopidogrelP2RY12 protein, humanReceptors, Purinergic P2Y12
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.