Evidence map›Paper›PMID 29653510›Full record

ArticleBMC infectious diseases2018

Factors affecting adherence to antiretroviral therapy among pregnant women in the Eastern Cape, South Africa.

Oladele Vincent Adeniyi, Anthony Idowu Ajayi, Daniel Ter Goon, Eyitayo Omolara Owolabi, Alfred Eboh, John Lambert

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 8 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Oladele Vincent AdeniyiDepartment of Family Medicine & Rural Health, Faculty of Health Science, Walter Sisulu University, Mthatha/East London Hospital Complex, Cecilia Makiwane Hospital, East London, South Africa.
Anthony Idowu AjayiDepartment of Sociology, Faculty of Social Sciences & Humanities, University of Fort Hare, 50, Church Street, East London, South Africa. ajayianthony@gmail.com.
Daniel Ter GoonDepartment of Nursing Sciences, Faculty of Health Sciences, University of Fort Hare, East London, South Africa.
Eyitayo Omolara OwolabiDepartment of Nursing Sciences, Faculty of Health Sciences, University of Fort Hare, East London, South Africa.
Alfred EbohDepartment of Sociology, Kogi State University, Anyigba, Kogi, State, P.M.B 1008, Nigeria.
John LambertDepartment of Infectious Diseases, Medicine and Sexual Health, Mater, Rotunda and University College, Dublin, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundContext-specific factors influence adherence to antiretroviral therapy (ART) among pregnant women living with HIV. Gaps exist in the understanding of the reasons for the variable outcomes of the prevention of mother-to-child transmission (PMTCT) programme at the health facility level in South Africa. This study examined adherence levels and reasons for non-adherence during pregnancy in a cohort of parturient women enrolled in the PMTCT programme in the Eastern Cape, South Africa.

methodsThis was a mixed-methods study involving 1709 parturient women in the Eastern Cape, South Africa. We conducted a multi-centre retrospective analysis of the mother-infant pair in the PMTCT electronic database in 2016. Semi-structured interviews of purposively selected parturient women with self-reported poor adherence (n = 177) were conducted to gain understanding of the main barriers to adherence. Binary logistic regression was used to determine the independent predictors of ART non-adherence.

resultsA high proportion (69.0%) of women reported perfect adherence. In the logistic regression analysis, after adjusting for confounding factors, marital status, cigarette smoking, alcohol use and non-disclosure to a family member were the independent predictors of non-adherence. Analysis of the qualitative data revealed that drug-related side-effects, being away from home, forgetfulness, non-disclosure, stigma and work-related demand were among the main reasons for non-adherence to ART.

conclusionsNon-adherence to the antiretroviral therapy among pregnant women in this setting is associated with lifestyle behaviours, HIV-related stigma and ART side-effects. In order to eliminate mother-to-child transmission of HIV, clinicians need to screen for these factors at every antenatal clinic visit.

Indexed as

Patient ComplianceAdultAnti-HIV AgentsCohort StudiesFemaleHIV InfectionsHumansInfantInfectious Disease Transmission, VerticalMothersPregnancyPregnancy Complications, InfectiousPregnant PeoplePrenatal CareRetrospective StudiesSocial StigmaAnti-HIV AgentsAdherenceAntiretroviral therapyElimination of mother-to-child transmissionHIVNon-adherencePrevention of mother-to-child transmissionSouth AfricaStigma

Identifiers

PMID29653510
PMCPMC5899366

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.