Evidence map›Paper›PMID 29653480›Full record

ArticleMicrobial drug resistance (Larchmont, N.Y.)2018

Changes in Macrolide Resistance Among Group A Streptococci in Serbia and Clonal Evolution of Resistant Isolates.

Ina Gajic, Vera Mijac, Lazar Ranin, Edita Grego, Dusan Kekic, Boris Jegorovic, Aleksandra Smitran, Suncica Popovic, Natasa Opavski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbial drug resistance (Larchmont, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ina Gajic1 Department of Bacteriology, Faculty of Medicine, Institute of Microbiology and Immunology, University of Belgrade , Belgrade, Serbia .
Vera Mijac1 Department of Bacteriology, Faculty of Medicine, Institute of Microbiology and Immunology, University of Belgrade , Belgrade, Serbia .
Lazar Ranin1 Department of Bacteriology, Faculty of Medicine, Institute of Microbiology and Immunology, University of Belgrade , Belgrade, Serbia .
Edita Grego2 Center for Microbiology, Institute of Public Health of Serbia "Dr. Milan Jovanović Batut ," Belgrade, Serbia .
Dusan Kekic1 Department of Bacteriology, Faculty of Medicine, Institute of Microbiology and Immunology, University of Belgrade , Belgrade, Serbia .
Boris Jegorovic3 Department of Tropical Diseases, Clinical Centre of Serbia, Clinic of Infectious and Tropical Diseases , Belgrade, Serbia .
Aleksandra Smitran4 Department of Microbiology and Immunology, Faculty of Medicine, University of Banja Luka , Banjaluka, Bosnia and Herzegovina.
Suncica Popovic1 Department of Bacteriology, Faculty of Medicine, Institute of Microbiology and Immunology, University of Belgrade , Belgrade, Serbia .
Natasa Opavski1 Department of Bacteriology, Faculty of Medicine, Institute of Microbiology and Immunology, University of Belgrade , Belgrade, Serbia .

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In Serbia, the frequency of macrolide-resistant group A streptococci (MRGASs) increased significantly from 2006 to 2009. MRGAS analysis in 2008 revealed the presence of three major clonal lineages: emm75/mefA, emm12/mefA, and emm77/ermTR. The aim of the present study was to determine the prevalence of macrolide resistance and to evaluate variations in the clonal composition of MRGASs. The study included 1,040 pharyngeal group A streptococci collected throughout Serbia, which were tested for antimicrobial susceptibility. MRGAS isolates were further characterized by the presence of resistance determinants, emm typing, and pulsed-field gel electrophoresis analysis. The prevalence of macrolide resistance was 9.6%, showing a slight decrease compared with the rate of 12.5% (2008). Tetracycline resistance was present in 6% of isolates, while norfloxacin nonsusceptibility detected for the first time in Serbia was 9.8%. The M phenotype dominated (84%), followed by the constitutive macrolides, lincosamides, and streptogramin B phenotype (12%). Five emm types were detected: emm75, emm12, emm1, emm28, and emm89. The emm75/mefA (62%), emm12/mefA (14%), and emm12/ermB/tetM (6%) were predominant clones and were found in both the present and the previous study periods at different frequencies. The major change was the loss of emm77/ermTR/tetO, which contributed to 15% of MRGASs in 2008.

Indexed as

AdolescentAnti-Bacterial AgentsChildChild, PreschoolClonal EvolutionDrug Resistance, BacterialFemaleGenes, BacterialGenotypeHumansLincosamidesMacrolidesMaleMicrobial Sensitivity TestsPhenotypeSerbiaAnti-Bacterial AgentsLincosamidesMacrolidesTetracyclineantibioticsbacteriaepidemiologygenotypingresistance

Identifiers

PMID29653480
PMCPMC6247989

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.