Evidence map›Paper›PMID 29653437›Full record

ArticleMultiple sclerosis and related disorders2018

Early infectious exposures are not associated with increased risk of pediatric-onset multiple sclerosis.

Leena Suleiman, Emmanuelle Waubant, Gregory Aaen, Anita Belman, Leslie Benson, Meghan Candee, Tanuja Chitnis, Mark Gorman, Manu Goyal, Benjamin Greenberg and 21 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis and related disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 20 institutions in 1 country.

Leena SuleimanPediatric Multiple Sclerosis Center, University of California San Francisco, San Francisco, CA, USA. Electronic address: leena.suleiman@ucsf.edu.
Emmanuelle WaubantPediatric Multiple Sclerosis Center, University of California San Francisco, San Francisco, CA, USA.
Gregory AaenPediatric Multiple Sclerosis Center, Loma Linda University Children's Hospital, Loma Linda, CA, USA.
Anita BelmanLourie Center for Pediatric Multiple Sclerosis, Stony Brook University Hospital, Stony Brook, New York, NY, USA.
Leslie BensonPediatric Multiple Sclerosis and Related Disorders Program, Boston Children's Hospital, Boston, MA, USA.
Meghan CandeePrimary Children's Hospital, University of Utah, Salt Lake City, UT, USA.
Tanuja ChitnisPartners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital, Boston, MA, USA.
Mark GormanPediatric Multiple Sclerosis and Related Disorders Program, Boston Children's Hospital, Boston, MA, USA.
Manu GoyalUniversity Pediatric Multiple Sclerosis and other Demyelinating Disease Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Benjamin GreenbergUniversity of Texas Southwestern, Dallas, TX, USA.
Yolanda HarrisCenter for Pediatric-Onset Demyelinating Disease, Children's Hospital of Alabama, University of Alabama, Birmingham, AL, USA.
Janace HartPediatric Multiple Sclerosis Center, University of California San Francisco, San Francisco, CA, USA.
Ilana KahnChildren's National Medical Center, Washington, DC, USA.
Lauren KruppPediatric Multiple Sclerosis Center, New York University, New York, NY, USA.
Timothy LotzeThe Blue Bird Circle Clinic for Multiple Sclerosis, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
Soe MarUniversity Pediatric Multiple Sclerosis and other Demyelinating Disease Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Manikum MoodleyMellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, OH, USA.
Jayne NessCenter for Pediatric-Onset Demyelinating Disease, Children's Hospital of Alabama, University of Alabama, Birmingham, AL, USA.
Bardia NourbakhshDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Mary RenselMellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, OH, USA.
Moses RodriguezMayo Clinic Pediatric Multiple Sclerosis Center, Mayo Clinic, Rochester, MN, USA.
John RoseDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.
Jennifer RubinLurie Children's Hospital of Chicago, Chicago, IL, USA.
Teri SchreinerRocky Mountain Multiple Sclerosis Center, Children's Hospital Colorado, University of Colorado at Denver, Aurora, CO, USA.
Jan-Mendelt TillemaMayo Clinic Pediatric Multiple Sclerosis Center, Mayo Clinic, Rochester, MN, USA.
Amy WaldmanChildren's Hospital of Philadelphia, Philadelphia, PA, USA.
Bianca Weinstock-GuttmanPediatric Multiple Sclerosis Center, Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, NY, USA.
T Charles CasperData Coordinating and Analysis Center, University of Utah, Salt Lake City, Utah, USA.
Michael WaltzData Coordinating and Analysis Center, University of Utah, Salt Lake City, Utah, USA.
Jennifer S GravesPediatric Multiple Sclerosis Center, University of California San Francisco, San Francisco, CA, USA.
Network of Pediatric Multiple Sclerosis Centers.
University of California, San Francisco · USUniversity of Utah · USBoston Children's Hospital · USCleveland Clinic · USMayo Clinic in Arizona · USUniversity of Alabama · USWashington University in St. Louis · USBaylor College of Medicine · USChildren's Hospital Colorado · USChildren's Hospital of Philadelphia · USChildren's National · USJacobs Institute · USJohns Hopkins University · USLoma Linda University Children's Hospital · USLurie Children's Hospital · USMassachusetts General Hospital · USMultiple Sclerosis Center Of Northeastern New York · USPrimary Children's Hospital · USStony Brook University Hospital · USThe University of Texas Southwestern Medical Center · US

Funding

ZESTRIL VS. VERAPAMIL IN THE TREATMENT OF HYPERTENSIONM01RR000585 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 1985 to 2006
$30.4M
Institutional Career Development CoreKL2TR002379 · NCATS · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2017 to 2026
$14.9M
Environmental and genetic risk factors for pediatric MSR01NS071463 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WAUBANT, EMMANUELLE LAURENCE · 2010 to 2015
$2.8M
NCATS NIH HHS KL2 TR002379NCRR NIH HHS M01 RR000585NINDS NIH HHS R01 NS071463
6 · The paper itself

Abstract

objectiveWe sought to determine if early infectious exposures such as daycare, early use of antibiotics, vaccinations and other germ exposures including pacifier use and playing on grass are associated with multiple sclerosis (MS) risk in children.

methodsThis was a case-control study of children with MS or clinically isolated syndrome (CIS) and healthy controls enrolled at sixteen clinics participating in the US Network of Pediatric MS Centers. Parents completed a comprehensive environmental questionnaire that captured early infectious exposures, habits, and illnesses in the first five years of life. A panel of at least two pediatric MS specialists confirmed diagnosis of participants. Association of early infectious variables with diagnosis was assessed via multivariable logistic regression analyses, adjusting for age, sex, race, ethnicity, US birth region, and socioeconomic status (SES).

resultsQuestionnaire responses for 326 eligible cases (mean age 14.9, 63.5% girls) and 506 healthy pediatric subjects (mean age 14.4, 56.9% girls) were included in analyses. History of flu with high fever before age five (p = 0.01), playing outside in grass and use of special products to treat head lice or scabies (p = 0.04) were associated with increased risk of MS in unadjusted analyses. In the multivariable model adjusted for age, sex, race, ethnicity, and mother's highest educational attainment, these results were not statistically significant. Notably, antibiotic use (p = 0.22) and regular daycare attendance before age 6 (p = 0.09) were not associated with odds of developing MS.

conclusionEarly infectious factors investigated in this study were not associated with MS risk.

Indexed as

Environmental ExposureAdolescentAge of OnsetCase-Control StudiesCommunicable DiseasesFemaleHumansLogistic ModelsMaleMultiple SclerosisMultivariate AnalysisRisk FactorsUnited StatesChildhood infectionEpidemiologyMultiple sclerosisNeonatal exposure

Identifiers

PMID29653437
PMCPMC6066281
OpenAlexW2791129730

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.