Evidence map›Paper›PMID 29653289›Full record

ArticleBiomaterials2018

Src activation decouples cell division orientation from cell geometry in mammalian cells.

Xiaoyan Sun, Hongsheng Qi, Xiuzhen Zhang, Li Li, Jiaping Zhang, Qunli Zeng, George S Laszlo, Bo Wei, Tianhong Li, Jianxin Jiang and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 2 countries.

Xiaoyan SunInstitute for Regenerative Cures, University of California, Davis, CA, USA; Department of Dermatology, University of California, Davis, CA, USA; Department of Ophthalmology, University of California, Davis, CA, USA; Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Trauma Center of Postgraduate Medical School, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, P.R. China.
Hongsheng QiKey Laboratory of Systems and Control, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, No. 55 Zhongguancun East Road, Beijing 100190, P.R. China.
Xiuzhen ZhangInstitute for Regenerative Cures, University of California, Davis, CA, USA; Department of Dermatology, University of California, Davis, CA, USA; Department of Ophthalmology, University of California, Davis, CA, USA.
Li LiInstitute for Regenerative Cures, University of California, Davis, CA, USA; Department of Dermatology, University of California, Davis, CA, USA; Department of Ophthalmology, University of California, Davis, CA, USA; Department of Respiratory Disease, Daping Hospital, Third Military Medical University, Chongqing 400042, P.R. China.
Jiaping ZhangInstitute for Regenerative Cures, University of California, Davis, CA, USA; Department of Dermatology, University of California, Davis, CA, USA; Department of Ophthalmology, University of California, Davis, CA, USA.
Qunli ZengInstitute for Regenerative Cures, University of California, Davis, CA, USA; Department of Dermatology, University of California, Davis, CA, USA; Department of Ophthalmology, University of California, Davis, CA, USA.
George S LaszloClinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, Seattle, USA.
Bo WeiDepartment of General Surgery, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, P.R. China.
Tianhong LiDivision of Hematology/Oncology, University of California Davis Comprehensive Cancer Center, 4501 X St #3016, Sacramento, USA.
Jianxin JiangState Key Laboratory of Trauma, Burns, and Combined Injury Research, Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, P.R. China.
Alex MogilnerCourant Institute, Department of Biology, New York University, 251 Mercer St, New York, USA.
Xiaobing FuWound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Trauma Center of Postgraduate Medical School, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, P.R. China. Electronic address: fuxiaobing@vip.sina.com.
Min ZhaoInstitute for Regenerative Cures, University of California, Davis, CA, USA; Department of Dermatology, University of California, Davis, CA, USA; Department of Ophthalmology, University of California, Davis, CA, USA. Electronic address: minzhao@ucdavis.edu.
California Institute for Regenerative Medicine · USChinese PLA General Hospital · CNUniversity of California, Davis · USAcademy of Mathematics and Systems Science · CNDaping Hospital · CNFred Hutch Cancer Center · USNew York University · USUC Davis Comprehensive Cancer Center

Funding

Molecular Generators at Corneal Wounds Produce and regulate the Wound Electrical SignalsR01EY019101 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ZHAO, MIN · 2010 to 2023
$5.2M
Guiding angiogenesisR21EB015737 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ZHAO, MIN · 2013 to 2014
$418k
NEI NIH HHS R01 EY019101NIBIB NIH HHS R21 EB015737
6 · The paper itself

Abstract

Orientation of cell division plane plays a crucial role in morphogenesis and regeneration. Misoriented cell division underlies many important diseases, such as cancer. Studies with Drosophila and C. elegance models show that Src, a proto-oncogene tyrosine-protein kinase, is a critical regulator of this aspect of mitosis. However, the role for Src in controlling cell division orientation in mammalian cells is not well understood. Using genetic and pharmacological approaches and two extracellular signals to orient cell division, we demonstrated a critical role for Src. Either knockout or pharmacological inhibition of Src would retain the fidelity of cell division orientation with the long-axis orientation of mother cells. Conversely, re-expression of Src would decouple cell division orientation from the pre-division orientation of the long axis of mother cells. Cell division orientation in human breast and gastric cancer tissues showed that the Src activation level correlated with the degree of mitotic spindle misorientation relative to the apical surface. Examination of proteins associated with cortical actin revealed that Src activation regulated the accumulation and local density of adhesion proteins on the sites of cell-matrix attachment. By analyzing division patterns in the cells with or without Src activation and through use of a mathematical model, we further support our findings and provide evidence for a previously unknown role for Src in regulating cell division orientation in relation to the pre-division geometry of mother cells, which may contribute to the misoriented cell division.

Indexed as

Cell DivisionCell ShapeAnimalsCell AdhesionElectricityFibroblastsHumansMCF-7 CellsMice, KnockoutMitosisProto-Oncogene Massrc-Family KinasesUp-RegulationMAS1 protein, humanProto-Oncogene Massrc-Family KinasesCell division orientationCell geometryCell polarityMitosisSrc

Identifiers

PMID29653289
PMCPMC5928802
OpenAlexW2796216041

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.