Evidence map›Paper›PMID 29653101›Full record

ArticleBiochemical and biophysical research communications2018

β1-integrin is a cell-autonomous factor mediating the Numb pathway for cardiac progenitor maintenance.

Brian C Gibbs, Lincoln Shenje, Peter Andersen, Matthew Miyamoto, Chulan Kwon

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Heart organoids and tissue models for modeling development and disease.Seminars in cell & developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Brian C GibbsDivision of Cardiology, Department of Medicine, Institute for Cell Engineering, Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Lincoln ShenjeDivision of Cardiology, Department of Medicine, Institute for Cell Engineering, Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Peter AndersenDivision of Cardiology, Department of Medicine, Institute for Cell Engineering, Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Matthew MiyamotoDivision of Cardiology, Department of Medicine, Institute for Cell Engineering, Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Chulan KwonDivision of Cardiology, Department of Medicine, Institute for Cell Engineering, Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. Electronic address: ckwon13@jhmi.edu.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

PATHOPHYSIOLOGY OF MYOCARDIAL DISEASEST32HL007227 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Chulan Kwon, WENDY S POST · 1985 to 2026
$21.2M
Regulation of Cardiac Progenitor MaintenanceR01HD086026 · NICHD · JOHNS HOPKINS UNIVERSITY · PI KWON, CHULAN · 2016 to 2020
$1.6M
American Heart Association-American Stroke Association 17GRNT33670432American Heart Association-American Stroke Association 18EIA33890038NHLBI NIH HHS T32 HL007227NICHD NIH HHS R01 HD086026
6 · The paper itself

Abstract

Proper control of multipotent/stem cell number and fate is essential for ensuing organ formation during development. β1-integrin, a subfamily of cell surface receptors, has a conserved role in maintenance of multipotent/stem cells, including renal progenitor cells, follicle stem cells, epidermal stem cells and neural stem cells. However, it remains unclear whether β1-integrin has a role in cardiac progenitor cell (CPC) development. Here we show that a mesodermal deletion of β1-integrin decreases Isl1

Indexed as

Signal TransductionAnimalsCell LineCell ProliferationEmbryo, MammalianGene DeletionHeartIntegrin beta1Intracellular Signaling Peptides and ProteinsMembrane ProteinsMice, KnockoutMyocytes, CardiacNerve Tissue ProteinsProtein BindingStem CellsIntegrin beta1Intracellular Signaling Peptides and ProteinsMembrane ProteinsNerve Tissue ProteinsNumbl protein, mouseNumb protein, mouseCardiac developmentCardiac progenitor expansionES/iPS cellsNumb/NumblSecond heart fieldβ1-integrin

Identifiers

PMID29653101
PMCPMC5924717
OpenAlexW2798267558

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.