ArticlePloS one2018
Epidemiology of sepsis in Brazil: Incidence, lethality, costs, and other indicators for Brazilian Unified Health System hospitalizations from 2006 to 2015.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The supplementation of L-carnitine in septic shock patients: Systematic review and meta-analysis.Clinics (Sao Paulo, Brazil) · 2022Pooled it
- Contemporary Trends in Global Mortality of Sepsis Among Young Infants Less Than 90 Days: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- Inflammation and aging-related disease: A transdisciplinary inflammaging framework.GeroScience · 2025Review
- Accuracy of the Identification and Prognosis Prediction of SOFA-Based Sepsis-3 for Septic Patients in the Emergency Department Compared With Sepsis-2.Emergency medicine international · 2025Article
- Frequency and Mortality of Adult Meningitis, Pneumonia, or Bacteremia in Colombia from 2015 to 2022: A Retrospective Database Study in a Health Maintenance Organization.Journal of health economics and outcomes research · 2025Article
- Uses of private health provider data for governance in low-income and middle-income countries: results from a scoping review.BMJ open · 2024Article
- Assessing the cost-effectiveness of capnography for end-tidal COAmerican heart journal plus : cardiology research and practice · 2024Article
- Understanding the biases to sepsis surveillance and quality assurance caused by inaccurate coding in administrative health data.Infection · 2024Article
- Article
- Aging-Associated Augmentation of Gut Microbiome Virulence Capability Drives Sepsis Severity.mBio · 2023Article
- The financial impact of neonatal sepsis on the Brazilian Unified Health System.Clinics (Sao Paulo, Brazil) · 2023Article
- Multidrug-Resistant Bacteria on Critically Ill Patients with Sepsis at Hospital Admission: Risk Factors and Effects on Hospital Mortality.Infection and drug resistance · 2023Article
- Temporal trends of medical cost and cost-effectiveness in sepsis patients: a Japanese nationwide medical claims database.Journal of intensive care · 2022Article
- Effect of Coronavirus Disease 2019 (Covid-19), a Nationwide Mass Casualty Disaster on Intensive Care Units: Clinical Outcomes and Associated Cost-of-Care.Disaster medicine and public health preparedness · 2022Article
- Riboflavin did not provide anti-inflammatory or antioxidant effects in an experimental model of sepsis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022Article
- Emergency medicine in Brazil: historical perspective, current status, and future challenges.International journal of emergency medicine · 2021Article
- Article
- Epidemiological Trend of Sepsis in Patients with Hospital Admissions Related to Hepatitis C in Spain (2000-2015): A Nationwide Study.Journal of clinical medicine · 2020Article
- Polymyxin for treatment of ventilator-associated pneumonia in a setting of high carbapenem resistance.PloS one · 2020Article
- The Prevalence, Risk Factors, and Outcomes of Sepsis in Critically Ill Patients in China: A Multicenter Prospective Cohort Study.Frontiers in medicine · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis is considered a major worldwide health burden, with high mortality and associated costs. Health indicators are essential to define strategies to improve the treatment of diseases, and the epidemiology information of sepsis in developing countries is scarce. Thus, the aim of this work is to assess trends in the incidence, lethality, costs, and other indicators of sepsis for Brazilian Unified Health System (SUS-Sistema Único de Saúde) hospitalizations for the period from January 2006 to December 2015. MATERIALS AND
methodsWe conducted this study using data from the SUS hospital information system. We selected registries of SUS hospitalizations of patients diagnosed with sepsis (total of 724,458 cases from 4,271 public and private Brazilian hospitals).
resultsFrom 2006 to 2015, the annual sepsis incidence increased 50.5% from 31.5/100,000 to 47.4/100,000 persons. The mean hospital length of stay (LOS) was 9.0 days. A total of 29.1% of the hospitalizations had admission to the intensive care unit (ICU) with a mean ICU LOS of 8.0 days. The mean cost per hospitalization was US$624.0 and for hospitalizations requiring intensive care was U$1,708.1. The overall sepsis lethality rate was 46.3%, and for hospitalizations with admission to the ICU, it was 64.5%. During the study period, the lethality rate for children/teenagers decreased 40.1%, but for all other age groups it increased 11.4%. The sepsis lethality rate in public hospitals (55.5%) was higher than private hospitals (37.0%) (p < 0.001). The mean hospitalization LOS for public hospitals (10.3 days) was higher than private hospitals (7.6 days) (p < 0.001).
conclusionsThe incidence and lethality rate of sepsis increased in SUS hospitalizations during the study period. The SUS's low reimbursement to hospitals for treating sepsis may be one of the reasons for the high lethality rate.
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