Evidence map›Paper›PMID 29652919›Full record

ArticlePloS one2018

Preparation and characterization of Fe3O4@Au-C225 composite targeted nanoparticles for MRI of human glioma.

Yaoqi Ge, Yuejiao Zhong, Guozhong Ji, Qianling Lu, Xinyu Dai, Zhirui Guo, Peng Zhang, Gang Peng, Kangzhen Zhang, Yuntao Li

Abstract read
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. State-of-the-art application of nanoparticles in radiotherapy: a platform for synergistic effects in cancer treatment.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025
    Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. FeJournal of translational medicine · 2021
    Article
  11. Multifunctional FeNanomaterials (Basel, Switzerland) · 2020
    Article
  12. Magnetic Nanoparticles as MRI Contrast Agents.Topics in current chemistry (Cham) · 2020
    Review
  13. Review
  14. Preparation and Characterization of FeInternational journal of nanomedicine · 2019
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yaoqi GeSecond Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Yuejiao ZhongJiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing, Jiangsu Province, China.
Guozhong JiSecond Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Qianling LuSecond Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Xinyu DaiSecond Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Zhirui GuoSecond Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Peng ZhangSecond Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Gang PengSecond Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Kangzhen ZhangSecond Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Yuntao LiSecond Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo study the characterization of Fe3O4@Au-C225 composite targeted MNPs.

methodsFe3O4@Au-C225 was prepared by the absorption method. The immunosorbent assay was used to evaluate its absorption efficiency at C225 Fc. ZETA SIZER3000 laser particle size analyzer, ultraviolet photometer and its characteristics were analyzed by VSM. the targeting effect of Fe3O4@Au-C225 composite targeted MNPs on U251 cells in vitro were detected by 7.0 Tesla Micro-MR; and subcutaneous transplanted human glioma in nude mice were performed the targeting effect in vivo after tail vein injection of Fe3O4@Au-C225 composite targeted MNPs by MRI.

resultsThe self-prepared Fe3O4@Au composite MNPs can adsorb C225 with high efficiency of adsorption so that Fe3O4@Au-C225 composite targeted MNPs were prepared successfully. Fe3O4@Au-C225 composite targeted MNPs favorably targeted human glioma cell line U251 in vitro; Fe3O4@Au-C225 composite targeted MNPs have good targeting ability to xenografted glioma on nude mice in vivo, and can be traced by MRI.

conclusionThe Fe3O4@Au-C225 composite targeted MNPs have the potential to be used as a tracer for glioma in vivo.

Indexed as

AdsorptionCell Line, TumorCetuximabGliomaGoldHumansMagnetic Resonance ImagingMagnetite NanoparticlesCetuximabGoldMagnetite Nanoparticles

Identifiers

PMID29652919
PMCPMC5898739

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.