ArticlePLoS biology2018
The rostromedial tegmental nucleus is essential for non-rapid eye movement sleep.
Article in PLoS biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 73 citations in OpenAlex.
- Motivation meets sleep: tuning arousal via nucleus accumbens and Basal Ganglia circuits.Npj biological timing and sleep · 2025Review
- Neural circuits and emotional processing in rapid eye movement sleep.Frontiers in psychiatry · 2025Review
- Neural Network Mechanisms Underlying General Anesthesia: Cortical and Subcortical Nuclei.Neuroscience bulletin · 2024Review
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- A Common Neuronal Ensemble in the Lateral Habenula Regulates Ciprofol Anesthesia in Mice.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Polysomnographic features associated with clonazepam and melatonin treatment in isolated REM sleep behavior disorder: Time for new therapeutic approaches?CNS neuroscience & therapeutics · 2024Article
- Recent advances in neural mechanism of general anesthesia induced unconsciousness: insights from optogenetics and chemogenetics.Frontiers in pharmacology · 2024Review
- Bright light treatment counteracts stress-induced sleep alterations in mice, via a visual circuit related to the rostromedial tegmental nucleus.PLoS biology · 2023Article
- Activation of Ventral Pallidum CaMKIIa-Expressing Neurons Promotes Wakefulness.Neurochemical research · 2023Article
- [The past, present and future of sleep medicine in China].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Review
- Parasubthalamic calretinin neurons modulate wakefulness associated with exploration in male mice.Nature communications · 2023Article
- Mechanisms of Sleep/Wake Regulation under Hypodopaminergic State: Insights from MitoPark Mouse Model of Parkinson's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Neuro-orchestration of sleep and wakefulness.Nature neuroscience · 2023Review
- Article
- GABAergic neurons in the rostromedial tegmental nucleus are essential for rapid eye movement sleep suppression.Nature communications · 2022Article
- A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy.Cell discovery · 2022Article
- An excitatory peri-tegmental reticular nucleus circuit for wake maintenance.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Motivational and Valence-Related Modulation of Sleep/Wake Behavior are Mediated by Midbrain Dopamine and Uncoupled from the Homeostatic and Circadian Processes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Article
- Roles of Neuropeptides in Sleep-Wake Regulation.International journal of molecular sciences · 2022Review
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Authors and funding
17 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rostromedial tegmental nucleus (RMTg), also called the GABAergic tail of the ventral tegmental area, projects to the midbrain dopaminergic system, dorsal raphe nucleus, locus coeruleus, and other regions. Whether the RMTg is involved in sleep-wake regulation is unknown. In the present study, pharmacogenetic activation of rat RMTg neurons promoted non-rapid eye movement (NREM) sleep with increased slow-wave activity (SWA). Conversely, rats after neurotoxic lesions of 8 or 16 days showed decreased NREM sleep with reduced SWA at lights on. The reduced SWA persisted at least 25 days after lesions. Similarly, pharmacological and pharmacogenetic inactivation of rat RMTg neurons decreased NREM sleep. Electrophysiological experiments combined with optogenetics showed a direct inhibitory connection between the terminals of RMTg neurons and midbrain dopaminergic neurons. The bidirectional effects of the RMTg on the sleep-wake cycle were mimicked by the modulation of ventral tegmental area (VTA)/substantia nigra compacta (SNc) dopaminergic neuronal activity using a pharmacogenetic approach. Furthermore, during the 2-hour recovery period following 6-hour sleep deprivation, the amount of NREM sleep in both the lesion and control rats was significantly increased compared with baseline levels; however, only the control rats showed a significant increase in SWA compared with baseline levels. Collectively, our findings reveal an essential role of the RMTg in the promotion of NREM sleep and homeostatic regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.