ArticlePLoS computational biology2018
Biobeam-Multiplexed wave-optical simulations of light-sheet microscopy.
Article in PLoS computational biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Synthetic data enables human-grade microtubule analysis with foundation models for segmentation.PLoS computational biology · 2026Article
- Using high-resolution microscopy data to generate realistic structures for electromagnetic FDTD simulations from complex biological models.Nature protocols · 2024Article
- Challenges and advances in optical 3D mesoscale imaging.Journal of microscopy · 2022Article
- Fluorescence based rapid optical volume screening system (OVSS) for interrogating multicellular organisms.Scientific reports · 2021Article
- Article
- How to define and optimize axial resolution in light-sheet microscopy: a simulation-based approach.Biomedical optics express · 2020Article
- Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice.eLife · 2019Article
- Development of a beam propagation method to simulate the point spread function degradation in scattering media.Optics letters · 2019Article
- BigStitcher: reconstructing high-resolution image datasets of cleared and expanded samples.Nature methods · 2019Article
- Simulating the imaging process in scattering tissue.Nature methods · 2018Article
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Authors and funding
5 authors.
Funding
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Abstract
Sample-induced image-degradation remains an intricate wave-optical problem in light-sheet microscopy. Here we present biobeam, an open-source software package that enables simulation of operational light-sheet microscopes by combining data from 105-106 multiplexed and GPU-accelerated point-spread-function calculations. The wave-optical nature of these simulations leads to the faithful reproduction of spatially varying aberrations, diffraction artifacts, geometric image distortions, adaptive optics, and emergent wave-optical phenomena, and renders image-formation in light-sheet microscopy computationally tractable.
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