ArticleJournal of the American Chemical Society2018
Suzuki-Miyaura Coupling of Simple Ketones via Activation of Unstrained Carbon-Carbon Bonds.
Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Ring Expansion via Palladium-Catalyzed Aryne Insertion into C-C Bonds of Benzocyclobutenones.Angewandte Chemie (International ed. in English) · 2025Article
- Deacylative arylation and alkynylation of unstrained ketones.Science advances · 2024Article
- What is a Cross-Coupling? An Argument for a Universal Definition.Tetrahedron · 2023Article
- Carbonylative N-Heterocyclization via Nitrogen-Directed C-C Bond Activation of Nonactivated Cyclopropanes.Journal of the American Chemical Society · 2022Article
- Rhodium-Catalyzed (4+1) Cycloaddition between Benzocyclobutenones and Styrene-Type Alkenes.Angewandte Chemie (International ed. in English) · 2022Article
- Temporary or removable directing groups enable activation of unstrained C-C bonds.Nature reviews. Chemistry · 2020Article
- Rhodium(II)-catalyzed multicomponent assembly of α,α,α-trisubstituted esters via formal insertion of O-C(spNature communications · 2020Article
- Radical-mediated C-C cleavage of unstrained cycloketones and DFT study for unusual regioselectivity.Nature communications · 2020Article
- Ruthenium-Catalyzed Reductive Cleavage of Unstrained Aryl-Aryl Bonds: Reaction Development and Mechanistic Study.Journal of the American Chemical Society · 2019Article
- Ruthenium(ii)-catalyzed chemoselective deacylative annulation of 1,3-diones with sulfoxonium ylidesChemical science · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Here, we describe that simple ketones can be efficiently employed as electrophiles in Suzuki-Miyaura coupling reactions via catalytic activation of unstrained C-C bonds. A range of common ketones, such as cyclopentanones, acetophenones, acetone and 1-indanones, could be directly coupled with various arylboronates in high site-selectivity, which offers a distinct entry to more functionalized aromatic ketones. Preliminary mechanistic study suggests that the ketone α-C-C bond was cleaved via oxidative addition.
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Registered trials
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