ArticleActa crystallographica. Section D, Structural biology2018
X-ray and UV radiation-damage-induced phasing using synchrotron serial crystallography.
Article in Acta crystallographica. Section D, Structural biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Standard Sample Preparation for Serial Femtosecond Crystallography.Biomolecules · 2025Review
- Obtaining anomalous and ensemble information from protein crystals from 220 K up to physiological temperatures.Acta crystallographica. Section D, Structural biology · 2023Article
- Single-support serial isomorphous replacement phasing.Acta crystallographica. Section D, Structural biology · 2022Article
- MicroED in natural product and small molecule research.Natural product reports · 2021Review
- Current status and future opportunities for serial crystallography at MAX IV Laboratory.Journal of synchrotron radiation · 2020Article
- Choosing your (Friedel) mates wisely: grouping data sets to improve anomalous signal.Acta crystallographica. Section D, Structural biology · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Specific radiation damage can be used to determine phases de novo from macromolecular crystals. This method is known as radiation-damage-induced phasing (RIP). One limitation of the method is that the dose of individual data sets must be minimized, which in turn leads to data sets with low multiplicity. A solution to this problem is to use data from multiple crystals. However, the resulting signal can be degraded by a lack of isomorphism between crystals. Here, it is shown that serial synchrotron crystallography in combination with selective merging of data sets can be used to determine high-quality phases for insulin and thaumatin, and that the increased multiplicity can greatly enhance the success rate of the experiment.
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