Evidence map›Paper›PMID 2965217›Full record

ArticleJournal of neurology, neurosurgery, and psychiatry1988

Determination of activated lymphocytes in peripheral blood of patients with multiple sclerosis.

A D Crockard, T A McNeill, J McKirgan, S A Hawkins

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurology, neurosurgery, and psychiatry, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 15 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

A D CrockardDepartment of Microbiology and Immunobiology, Queen's University of Belfast, Royal Victoria Hospital, Northern Ireland.
T A McNeill
J McKirgan
S A Hawkins
University of Ulster · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using monoclonal antibodies Ta1 and CD25 (interleukin-2 receptor: I-2R) and flow cytometry, the levels of activated lymphocytes in the peripheral blood of 50 patients with multiple sclerosis (16 relapsing inactive; 14 relapsing active; 20 chronic progressive) and 20 normal subjects were investigated. No significant differences were observed in the percentage or absolute numbers of Ta1 and IL-2R reactive lymphocytes between the normal and multiple sclerosis patient groups, irrespective of disease activity. Monitoring peripheral blood lymphocytes with respect to these markers would appear to have little value in the management of multiple sclerosis.

Indexed as

Lymphocyte ActivationHumansKiller Cells, NaturalLeukocyte CountMultiple SclerosisReceptors, ImmunologicReceptors, Interleukin-2T-LymphocytesT-Lymphocytes, Helper-InducerT-Lymphocytes, RegulatoryReceptors, ImmunologicReceptors, Interleukin-2

Identifiers

PMID2965217
PMCPMC1032729
OpenAlexW1985039935

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.