ArticleMinerva endocrinologica2019
Associations between vitamin D levels and polycystic ovary syndrome phenotypes.
Article in Minerva endocrinologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and influencing factors of vitamin D deficiency in women with polycystic ovary syndrome: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Effects of Vitamin D3 Treatment on Polycystic Ovary Symptoms: A Prospective Double-Blind Two-Phase Randomized Controlled Clinical Trial.Nutrients · 2025Trial
- Unraveling the Complexity of Polycystic Ovary Syndrome: Biomarkers for Diagnosis, Prognosis, and Treatment.Current pharmaceutical design · 2026Review
- Vitamin D in Reproductive Health Disorders: A Narrative Review Focusing on Infertility, Endometriosis, and Polycystic Ovarian Syndrome.International journal of molecular sciences · 2025Review
- Is vitamin D deficiency a more frequent finding in hirsutism or not?Archives of dermatological research · 2024Article
- Association of Vitamin D with Perfluorinated Alkyl Acids in Women with and without Non-Obese Polycystic Ovary Syndrome.Biomedicines · 2024Article
- Systematic low-grade chronic inflammation and intrinsic mechanisms in polycystic ovary syndrome.Frontiers in immunology · 2024Review
- PCOS Physiopathology and Vitamin D Deficiency: Biological Insights and Perspectives for Treatment.Journal of clinical medicine · 2022Review
- Low Serum 25-Hydroxyvitamin D Levels Are Associated With Hyperandrogenemia in Polycystic Ovary Syndrome: A Cross-Sectional Study.Frontiers in endocrinology · 2022Article
- PCOS and nutritional approaches: Differences between lean and obese phenotype.Metabolism open · 2021Article
- Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.Autophagy · 2021Review
- Influence of Vitamin D on the Vasoactive Effect of Estradiol in a Rat Model of Polycystic Ovary Syndrome.International journal of molecular sciences · 2021Article
- Review
- Effect of Vitamin D Status on Vascular Function of the Aorta in a Rat Model of PCOS.Oxidative medicine and cellular longevity · 2021Article
- Is there any association between vitamin D levels and polycystic ovary syndrome (PCOS) phenotypes?Archives of endocrinology and metabolism · 2020Article
- Polycystic ovary syndrome: new insights on the puzzle of adiposity, chronic low-grade inflammation and metabolic disturbances.Archives of endocrinology and metabolism · 2020Article
- Article
- Effects of Vitamin D Deficiency on Proliferation and Autophagy of Ovarian and Liver Tissues in a Rat Model of Polycystic Ovary Syndrome.Biomolecules · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundStudies comparing serum 25-hydroxyvitamin D concentrations in women with and without polycystic ovary syndrome (PCOS) have produced inconsistent results. Additionally, no previous studies have evaluated associations between vitamin D and specific PCOS phenotypes.
methodsThis case-control study was conducted among women undergoing intrauterine insemination. Cases (N.=137) were diagnosed with PCOS and then further classified into 3 diagnostic phenotypes based on combinations of the Rotterdam criteria (ovulatory dysfunction+polycystic ovaries [N.=55]; ovulatory dysfunction +androgen excess [N.=15]; and ovulatory dysfunction, +polycystic ovaries, +androgen excess [N.=67]). Controls (N.=103) were ovulatory women without PCOS who were undergoing IUI. Serum total 25-hydroxyvitamin D concentrations were categorized as deficient (≤20 ng/mL), insufficient (21-29 ng/mL), and sufficient (≥30 ng/mL). Prevalence odds ratios (PORs) were calculated using logistic regression.
resultsA higher proportion (59.9%) of PCOS cases lacked sufficient vitamin D levels compared to controls (47.6%; P value=0.06). The odds of vitamin D deficiency in all PCOS cases were twice that of controls (POR=2.03, 95% CI 0.97-4.26); however, the association was attenuated after adjusting for Body Mass Index (BMI) and race/ethnicity (adjPOR=1.43, 95% CI 0.62, 3.26). When examining PCOS phenotypes exhibiting androgen excess, crude associations were observed for deficient vitamin D levels (unadjPOR=2.93, 95% CI: 1.27, 6.77); however, the association decreased after adjustment for BMI and race/ethnicity (adjPOR=2.03, 95% CI: 0.79, 5.19).
conclusionsVitamin D deficiency occurred more frequently in PCOS cases with androgen excess, but associations were attenuated after adjusting for BMI and race/ethnicity. Combining etiologically distinct PCOS subgroups may obscure associations with lower vitamin D levels and other potential risk factors.
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