Evidence map›Paper›PMID 29651896›Full record

SynthesisJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2019

Cerebral serotonin transporter measurements with [

Martin Nørgaard, Melanie Ganz, Claus Svarer, Ling Feng, Masanori Ichise, Rupert Lanzenberger, Mark Lubberink, Ramin V Parsey, Marios Politis, Eugenii A Rabiner and 7 more

Open access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Trial
  2. Different preprocessing strategies lead to different conclusions: A [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Trial
  3. Article
  4. Review
  5. Serotonin 1B receptor density mapping of the human brainstem using positron emission tomography and autoradiography.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  6. Imaging Histamine H3 Receptors with Positron Emission Tomography.Current topics in behavioral neurosciences · 2022
    Review
  7. Article
  8. Reproducibility of findings in modern PET neuroimaging: insight from the NRM2018 grand challenge.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  9. False positive rates in positron emission tomography (PET) voxelwise analyses.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  10. Article
  11. Article
  12. Guidelines for the content and format of PET brain data in publications and archives: A consensus paper.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Article
  13. Article
  14. Article
  15. Article
  16. Brain PET Poster Sessions PP01-M01 to PP02-N07.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 11 institutions in 7 countries.

Martin Nørgaard1 Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Melanie Ganz1 Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Claus Svarer1 Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Ling Feng1 Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Masanori Ichise4 Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Rupert Lanzenberger5 Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Mark Lubberink6 Department of Nuclear Medicine and Positron Emission Tomography, Uppsala University, Uppsala, Sweden.
Ramin V Parsey7 Department of Psychiatry, School of Medicine, Stony Brook University, Stony Brook, NY, USA.
Marios Politis8 Neurodegeneration Imaging Group, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.
Eugenii A Rabiner9 Imanova Limited, London, UK.
Mark Slifstein7 Department of Psychiatry, School of Medicine, Stony Brook University, Stony Brook, NY, USA.
Vesna Sossi11 Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada.
Tetsuya Suhara4 Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Peter S Talbot12 Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Federico Turkheimer13 Department of Neuroimaging, King's College London, London, UK.
Stephen C Strother14 Rotman Research Institute at Baycrest, University of Toronto, Toronto, Canada.
Gitte M Knudsen1 Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Copenhagen University Hospital · DKKing's College London · GBNational Institutes for Quantum Science and Technology · JPRigshospitalet · DKStony Brook University · USBaycrest Hospital · CAMedical University of Vienna · ATUniversity of British Columbia · CAUniversity of Manchester · GBUppsala University · SEWellcome Centre for Human Neuroimaging · GB

Funding

Multimodal brain imaging of serotoninR21EB018964 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI GREVE, DOUGLAS NOWLIN, KNUDSEN, GITTE MOOS · 2014 to 2015
$423k
Medical Research Council G1100809Medical Research Council MR/N026063/1NIBIB NIH HHS R21 EB018964
6 · The paper itself

Abstract

Positron Emission Tomography (PET) imaging has become a prominent tool to capture the spatiotemporal distribution of neurotransmitters and receptors in the brain. The outcome of a PET study can, however, potentially be obscured by suboptimal and/or inconsistent choices made in complex processing pipelines required to reach a quantitative estimate of radioligand binding. Variations in subject selection, experimental design, data acquisition, preprocessing, and statistical analysis may lead to different outcomes and neurobiological interpretations. We here review the approaches used in 105 original research articles published by 21 different PET centres, using the tracer [

Indexed as

BrainPositron-Emission TomographyBenzylaminesCarbon RadioisotopesFemaleHumansMaleRadiopharmaceuticalsSerotonin Plasma Membrane Transport ProteinsBenzylaminesCarbon RadioisotopesN,N-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamineRadiopharmaceuticalsSerotonin Plasma Membrane Transport Proteins[C]DASBdata sharingkinetic modelingPositron Emission Tomographypreprocessing

Identifiers

PMID29651896
PMCPMC6365604
OpenAlexW2789366119

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.