ArticleJournal of Korean medical science2018
Biochemical Predictors of Early Onset Non-Alcoholic Fatty Liver Disease in Young Children with Obesity.
Article in Journal of Korean medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Prevalence of nonalcoholic fatty liver disease among overweight and obese children from a teaching institution of Jharkhand: A cross-sectional study.Journal of family medicine and primary care · 2025Article
- Association of fatty liver with serum gamma-glutamyltransferase and uric acid in obese children in a tertiary care centre.BMC pediatrics · 2025Article
- Association between the arm circumference and non-alcoholic fatty liver disease in American children and adolescence: a population-based analysis.Frontiers in public health · 2024Article
- Expanding Pharmacists' Role in the Management of Non-Alcoholic Fatty Liver Disease.Pharmacy (Basel, Switzerland) · 2023Review
- Article
- Changes of cardiolipin involve in the occurrence and development of mitochondrial dysfunction associated with non-alcoholic fatty liver disease.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021Article
- The triglycerides and glucose index is strongly associated with hepatic steatosis in children with overweight or obesity.European journal of pediatrics · 2021Article
- Article
- Association between the non-HDL-cholesterol to HDL-cholesterol ratio and non-alcoholic fatty liver disease in Chinese children and adolescents: a large single-center cross-sectional study.Lipids in health and disease · 2020Article
- Elevated Alanine Aminotransferase in Early Pregnancy and Subsequent Development of Gestational Diabetes and Preeclampsia.Journal of Korean medical science · 2020Article
- High uric acid, reduced glomerular filtration rate and non-alcoholic fatty liver in young people with obesity.Journal of endocrinological investigation · 2020Article
- Circulating Hsp90 Isoform Levels in Overweight and Obese Children and the Relation to Nonalcoholic Fatty Liver Disease: Results from a Cross-Sectional Study.Disease markers · 2019Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
backgroundThe prevalence of metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD) and their associated risk factors are not well-established in young children with obesity. The purpose of this study was to evaluate the prevalence of early onset NAFLD and identify its biochemical predictors in obese children aged less than 10 years.
methodsAnthropometric measurements, blood pressure, laboratory tests, and abdominal ultrasonography (USG) were performed in all subjects. National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria for MS diagnosis and liver enzymes and USG for NAFLD diagnosis were assessed.
resultsA total of 356 children with obesity (233 boys, 123 girls) were included, with 172 children age ≤ 10 years and 184 adolescents. The prevalence of MS was 23.3% in young children and 35.3% in adolescents (P = 0.020); while the prevalence of NAFLD was 36.0% and 70.7%, respectively (P = 0.001). In obese children aged 10 years or less, there were significant differences in levels of serum γ-glutamyltranspeptidase (γGT) (P < 0.001), triglycerides (P = 0.042), and homeostatic model assessment of insulin resistance (P < 0.001) between the non-NAFLD and the NAFLD group. Multivariate logistic regression analysis revealed significant increase in serum γGT and uric acid levels in young children.
conclusionAlthough MS and NAFLD were more prevalent in adolescents, young children also demonstrated MS and NAFLD as obesity-related complications. Elevated serum γGT and uric acid levels may serve as biochemical predictors in detecting NAFLD in young children with obesity before investigation with abdominal USG.
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