Evidence map›Paper›PMID 29651771›Full record

ArticleEuropean radiology2018

Remote brain microhaemorrhages may predict haematoma in glioma patients treated with radiation therapy.

Augustin Lecler, Frédérique Charbonneau, Dimitri Psimaras, Marie-Astrid Metten, Antoine Gueguen, Khe Hoang Xuan, Loic Feuvret, Julien Savatovsky

Abstract read
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In one paragraph

Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Augustin LeclerDepartment of Radiology, Fondation Ophtalmologique Adolphe de Rothschild, 25 rue Manin, 75019, Paris, France. alecler@for.paris.ORCID http://orcid.org/0000-0001-7869-1815
Frédérique CharbonneauDepartment of Radiology, Fondation Ophtalmologique Adolphe de Rothschild, 25 rue Manin, 75019, Paris, France.
Dimitri PsimarasDepartment of Neurology, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Paris, France.
Marie-Astrid MettenClinical Research Unit, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.
Antoine GueguenDepartment of Neurology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.
Khe Hoang XuanDepartment of Neurooncology, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Paris, France.
Loic FeuvretDepartment of Radiotherapy, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Paris, France.
Julien SavatovskyDepartment of Radiology, Fondation Ophtalmologique Adolphe de Rothschild, 25 rue Manin, 75019, Paris, France.
Fondation Ophtalmologique Adolphe de Rothschild · FRSorbonne Université · FRUniversité Sorbonne Paris Nord · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the prevalence of cerebral remote microhaemorrhages (RMH) and remote haematomas (RH) using magnetic resonance susceptibility-weighted imaging (SWI) among patients treated for gliomas during follow-up.

methodsWe conducted a retrospective single centre longitudinal study on 58 consecutive patients treated for gliomas from January 2009 through December 2010. Our institutional review board approved this study. We evaluated the presence and number of RMH and RH found outside the brain tumour on follow-up MR imaging. We performed univariate and bivariate analyses to identify predictors for RMH and RH and Kaplan-Meier survival analysis techniques.

resultsTwenty-five (43%) and four patients (7%) developed at least one RMH or RH, respectively, during follow-up. The risk was significantly higher for patients who received radiation therapy (49% and 8% versus 0%) (p = 0.02). The risk of developing RH was significantly higher in patients with at least one RMH and a high burden of RMH. The mean age of those presenting with at least one RMH or RH was significantly lower.

conclusionsRMH were common in adult survivors of gliomas who received radiation therapy and may predict the onset of RH during follow-up, mainly in younger patients. KEY POINTS: • Brain RMH and RH are significantly more likely to occur after RT. • RMH occur in almost half of the patients treated with RT. • RMH and RH are significantly more frequent in younger patients. • RH occur only in patients with RMH.

Indexed as

Diffusion Magnetic Resonance ImagingAdultAgedBrain NeoplasmsCerebral HemorrhageFemaleGliomaHematomaHumansLongitudinal StudiesMaleMiddle AgedRadiotherapyRetrospective StudiesSurvival AnalysisDiagnostic imagingIntracranial haemorrhagesMagnetic resonance imagingRadiation effectsRadiotherapy

Identifiers

PMID29651771
OpenAlexW2802316940

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.