Evidence map›Paper›PMID 29651696›Full record

ArticleInternational urology and nephrology2018

Diversity of the midstream urine microbiome in adults with chronic kidney disease.

Holly Kramer, Gina Kuffel, Krystal Thomas-White, Alan J Wolfe, Kavitha Vellanki, David J Leehey, Vinod K Bansal, Linda Brubaker, Robert Flanigan, Julia Koval and 2 more

Open access · hybridAbstract read
In one paragraph

Article in International urology and nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Microbes and GFR in Health and CKD in Mice.Journal of the American Society of Nephrology : JASN · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Preanalytical, Analytical and Postanalytical Analyses onDiagnostics (Basel, Switzerland) · 2024
    Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. The Urobiome and Its Role in Overactive Bladder.International neurourology journal · 2022
    Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Holly KramerDepartment of Public Health Sciences, Loyola University Chicago, 2160 S. First Avenue, Maywood, IL, 60153, USA.
Gina KuffelDepartment of Public Health Sciences, Loyola University Chicago, 2160 S. First Avenue, Maywood, IL, 60153, USA.
Krystal Thomas-WhiteDepartments of Microbiology and Immunology, Loyola University Chicago, Maywood, IL, USA.
Alan J WolfeDepartments of Microbiology and Immunology, Loyola University Chicago, Maywood, IL, USA.
Kavitha VellankiMedicine, Division of Nephrology and Hypertension, Loyola University Chicago, Maywood, IL, USA.
David J LeeheyMedicine, Division of Nephrology and Hypertension, Loyola University Chicago, Maywood, IL, USA.
Vinod K BansalMedicine, Division of Nephrology and Hypertension, Loyola University Chicago, Maywood, IL, USA.
Linda BrubakerObstetrics and Gynecology, Loyola University Chicago, Maywood, IL, USA.
Robert FlaniganUrology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
Julia KovalMedicine, Division of Nephrology and Hypertension, Loyola University Chicago, Maywood, IL, USA.
Anuradha WadhwaMedicine, Division of Nephrology and Hypertension, Loyola University Chicago, Maywood, IL, USA.
Michael J ZillioxDepartment of Public Health Sciences, Loyola University Chicago, 2160 S. First Avenue, Maywood, IL, 60153, USA. mizilliox@luc.edu.
Loyola University Chicago · USEdward Hines, Jr. VA Hospital · USInstitute for Female Pelvic Medicine and Reconstructive Surgery · US

Funding

The Female Urinary Microbiome and Urinary IncontinenceR01DK104718 · NIDDK · LOYOLA UNIVERSITY CHICAGO · PI BRUBAKER, LINDA, WOLFE, ALAN J · 2016 to 2020
$3.1M
The Female Urinary Microbiome and Urinary IncontinenceR56DK104718 · NIDDK · LOYOLA UNIVERSITY CHICAGO · PI BRUBAKER, LINDA, WOLFE, ALAN J · 2015 to 2015
$300k
National Institute of Diabetes and Digestive and Kidney Diseases DK104718NIDDK NIH HHS R01 DK104718NIDDK NIH HHS R56 DK104718
6 · The paper itself

Abstract

purposeTo examine the characteristics of the midstream urine microbiome in adults with stage 3-5 non-dialysis-dependent chronic kidney disease (CKD).

methodsPatients with non-dialysis-dependent CKD (estimated glomerular filtration rate [eGFR] < 60 ml/min/1.73 m

resultsThe cohort of 41 women and 36 men with detectable bacterial DNA in their urine samples had a mean age of 71.5 years (standard deviation [SD] 7.9) years (range 60-91 years). The majority were white (68.0%) and a substantial minority were African-American (29.3%) The mean eGFR was 27.2 (SD 13.6) ml/min/1.73 m

conclusionsThe midstream voided urine microbiome of older adults with stage 3-5 non-dialysis-dependent CKD is diverse. Greater microbiome diversity is associated with higher eGFR.

Indexed as

Glomerular Filtration RateMicrobiotaAgedAged, 80 and overBacteriuriaBiodiversityCorynebacteriumEnterobacteriaceaeEscherichiaFemaleGardnerellaHumansKidney Failure, ChronicLactobacillusMaleMiddle AgedRNA, Ribosomal, 16SChronic kidney diseaseMicrobiome diversityUrinary microbiomeUrinary symptoms

Identifiers

PMID29651696
PMCPMC5986845
OpenAlexW2797560012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.