ArticlePsychopharmacology2018
Efficacy and side effects of baclofen and the novel GABA
Article in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Reducing effects of isoliquiritigenin, a naturally occurring GABAPsychopharmacology · 2026Article
- GABAFrontiers in pharmacology · 2026Review
- A synergistic effect of herb and acupuncture on the methamphetamine.Integrative medicine research · 2024Article
- Review
- GABACurrent topics in behavioral neurosciences · 2022Article
- Reducing effect of the novel positive allosteric modulator of the GABAPsychopharmacology · 2022Article
- GABACurrent topics in behavioral neurosciences · 2022Article
- The GABAPsychopharmacology · 2021Article
- Recent Advances in the Potential of Positive Allosteric Modulators of the GABAB Receptor to Treat Alcohol Use Disorder.Alcohol and alcoholism (Oxford, Oxfordshire) · 2021Review
- The Novel Positive Allosteric Modulator of the GABAFrontiers in cell and developmental biology · 2021Article
- Cocaine addicted rats show reduced neural activity as revealed by manganese-enhanced MRI.Scientific reports · 2020Article
- Building better strategies to develop new medications in Alcohol Use Disorder: Learning from past success and failure to shape a brighter future.Neuroscience and biobehavioral reviews · 2019Review
- Potential of GABACNS drugs · 2019Review
- Pavlovian to Instrumental Transfer Responses Do Not Correlate With Addiction-Like Behavior in Rats.Frontiers in behavioral neuroscience · 2019Article
- Suppressing Effect of Baclofen on Multiple Alcohol-Related Behaviors in Laboratory Animals.Frontiers in psychiatry · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
rationalePreclinical studies suggest that the GABA
objectiveTo test efficacy and adverse effects of baclofen and the novel GABA
methodsWe used a well-characterized rat model of long-term alcohol consumption with repeated deprivation phases that result in compulsive alcohol drinking in a relapse situation, and a rat model of long-term intravenous cocaine self-administration resulting in key symptoms of addictive behavior. We tested repeated baclofen (0, 1, and 3 mg/kg; i.p.) and CMPPE doses (0, 10, and 30 mg/kg; i.p.) in relapse-like situations, in either alcohol or cocaine addicted-like rats.
resultsBaclofen produced a weak anti-relapse effect at the highest dose in alcohol addicted-like rats, and this effect was mainly due to the treatment-induced sedation. CMPPE had a better profile, with a dose-dependent reduction of relapse-like alcohol drinking and without any signs of sedation. The cue-induced cocaine-seeking response was completely abolished by both compounds.
conclusionPositive allosteric modulation of the GABA
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.