ArticleScience advances2018
Evo-devo models of tooth development and the origin of hominoid molar diversity.
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Lateral inhibition governs ancestral cellular patterning in fossil and extant liverworts.Development (Cambridge, England) · 2026Article
- You Should Look a Gift Ungulate in the Mouth: Using 2D Occlusal Cheek Tooth Morphology to Study the Evolution of Molarization in Ungulates.Integrative organismal biology (Oxford, England) · 2026Article
- Spatiotemporal Molecular Architecture of Lineage Allocation and Cellular Organization in Tooth Morphogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Evaluating predictions of the patterning cascade model of crown morphogenesis in the human lower mixed and permanent dentition.PloS one · 2024Article
- Nutritional supplementation, tooth crown size, and trait expression in individuals from Tezonteopan, Mexico.PloS one · 2024Article
- Mammalian dental diversity: an evolutionary template for regenerative dentistry.Frontiers in dental medicine · 2023Review
- Tracing PRX1International journal of oral science · 2022Article
- Biomechanical Comparison of Six Different Root-Analog Implants and the Conventional Morse Taper Implant by Finite Element Analysis.Frontiers in genetics · 2022Article
- Article
- Testing the inhibitory cascade model in the Middle Pleistocene Sima de los Huesos (Sierra de Atapuerca, Spain) hominin sample.Journal of anatomy · 2021Review
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Authors and funding
5 authors.
Funding
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Abstract
The detailed anatomical features that characterize fossil hominin molars figure prominently in the reconstruction of their taxonomy, phylogeny, and paleobiology. Despite the prominence of molar form in human origins research, the underlying developmental mechanisms generating the diversity of tooth crown features remain poorly understood. A model of tooth morphogenesis-the patterning cascade model (PCM)-provides a developmental framework to explore how and why the varying molar morphologies arose throughout human evolution. We generated virtual maps of the inner enamel epithelium-an indelibly preserved record of enamel knot arrangement-in 17 living and fossil hominoid species to investigate whether the PCM explains the expression of all major accessory cusps. We found that most of the variation and evolutionary changes in hominoid molar morphology followed the general developmental rule shared by all mammals, outlined by the PCM. Our results have implications for the accurate interpretation of molar crown configuration in hominoid systematics.
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