ArticleScience advances2018
Differential expression of voltage-gated sodium channels in afferent neurons renders selective neural block by ionic direct current.
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Effect of dual direct and alternating currents on pain induced by blood sampling and intramuscular injection processes.Pain management · 2025Trial
- Temporal properties of direct current sensory block of the rat sciatic nerve using the C-fiber reflex.Journal of neural engineering · 2025Article
- Effect of Ultrasonic Treatment of Dispersed Carbon Nanocomposite Media on the Formation, Electrical Conductivity, and Degradation of a Hydrogel for Metallic Stimulation Electrodes.Gels (Basel, Switzerland) · 2025Article
- Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat.Journal of visualized experiments : JoVE · 2025Article
- Closed-loop electrical block of vagus nerve scales from rodent to porcine cardiac models.Journal of neural engineering · 2025Article
- Peripheral direct current reduces naturally evoked nociceptive activity at the spinal cord in rodent models of pain.Journal of neural engineering · 2024Article
- Galvanic vs. pulsatile effects on decision-making networks: reshaping the neural activation landscape.Journal of neural engineering · 2024Article
- Spinal neuromodulation using ultra low frequency waveform inhibits sensory signaling to the thalamus and preferentially reduces aberrant firing of thalamic neurons in a model of neuropathic pain.Frontiers in neuroscience · 2024Article
- Model Analysis of Post-Stimulation Block of a Myelinated Axon by Direct Current.IEEE transactions on bio-medical engineering · 2023Article
- A Cuff Lead for Delivering Ionic Direct Current (iDC) to Block Neural Activities of Sciatic Nerve.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2023Article
- The Significance of Concentration-dependent Components in Computational Models of C-Fibers.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2023Article
- Steering Toward Normative Wide-Dynamic-Range Neuron Activity in Nerve-Injured Rats With Closed-Loop Peripheral Nerve Stimulation.Neuromodulation : journal of the International Neuromodulation Society · 2023Article
- Identification of key factors driving inflammation-induced sensitization of muscle sensory neurons.Frontiers in neuroscience · 2023Article
- Electrochemical modulation enhances the selectivity of peripheral neurostimulation in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A Hydrogel-Based Microfluidic Nerve Cuff for Neuromodulation of Peripheral Nerves.Micromachines · 2021Article
- Model Analysis of Post-Stimulation Effect on Axonal Conduction and Block.IEEE transactions on bio-medical engineering · 2021Article
- On-chip ionic current sensor.Applied physics. A, Materials science & processing · 2021Article
- Combining direct current and kilohertz frequency alternating current to mitigate onset activity during electrical nerve block.Journal of neural engineering · 2021Article
- Article
- A microfluidic system integrated with shape memory alloy valves for a safe direct current delivery system.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2020Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
Abstract
The assertion that large-diameter nerve fibers have low thresholds and small-diameter fibers have high thresholds in response to electrical stimulation has been held in a nearly axiomatic regard in the field of neuromodulation and neuroprosthetics. In contrast to the short pulses used to evoke action potentials, long-duration ionic direct current has been shown to block neural activity. We propose that the main determinant of the neural sensitivity to direct current block is not the size of the axon but the types of voltage-gated sodium channels prevalent in its neural membrane. On the basis of the variants of voltage-gated sodium channels expressed in different types of neurons in the peripheral nerves, we hypothesized that the small-diameter nociceptive fibers could be preferentially blocked. We show the results of a computational model and in vivo neurophysiology experiments that offer experimental validation of this novel phenomenon.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.