Evidence map›Paper›PMID 29651287›Full record

ArticleFrontiers in immunology2018

Neutralizing Anti-Cytokine Autoantibodies Against Interferon-α in Immunodysregulation Polyendocrinopathy Enteropathy X-Linked.

Jacob M Rosenberg, Maria E Maccari, Federica Barzaghi, Eric J Allenspach, Claudio Pignata, Giovanna Weber, Troy R Torgerson, Paul J Utz, Rosa Bacchetta

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
  2. Approach to the patient with APS-1/APECED.The Journal of clinical endocrinology and metabolism · 2026
    Article
  3. High risk of hypoxemic COVID-19 pneumonia in myasthenia gravis patients with type I IFN autoantibodies.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
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  8. Review
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  10. Article
  11. Review
  12. Article
  13. Aire Mutations and Autoimmune Diseases.Advances in experimental medicine and biology · 2025
    Review
  14. Review
  15. Article
  16. A sensitive assay for measuring whole-blood responses to type I IFNs.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Aire in Autoimmunity.Annual review of immunology · 2024
    Review
  18. The ouroboros of autoimmunity.Nature immunology · 2024
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 3 countries.

Jacob M RosenbergDepartment of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Maria E MaccariCenter for Chronic Immunodeficiency, Faculty of Medicine, University Medical Center, University of Freiburg, Freiburg, Germany.
Federica BarzaghiSan Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy.
Eric J AllenspachUniversity of Washington School of Medicine and Seattle Children's Hospital, Seattle, WA, United States.
Claudio PignataPediatric Section, Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
Giovanna WeberDepartment of Pediatrics, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy.
Troy R TorgersonUniversity of Washington School of Medicine and Seattle Children's Hospital, Seattle, WA, United States.
Paul J UtzDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Rosa BacchettaDepartment of Pediatric Stem Cell Transplantation and Regenerative Medicine, Stanford School of Medicine, Stanford, CA, United States.
Seattle Children's Hospital · USHarvard University · USStanford Medicine · USStanford University · USThe San Raffaele Telethon Institute for Gene Therapy · ITUniversity Medical Center Freiburg · DEUniversity of Naples Federico II · ITVita-Salute San Raffaele University · IT

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007365 · NIGMS · STANFORD UNIVERSITY · PI CHUA, KATRIN F · 1985 to 2021
$33.8M
Ultra-Fast Epigenomic Maps for Monitoring AutoimmunityU19AI110491 · NIAID · STANFORD UNIVERSITY · PI MAECKER, HOLDEN T. · 2014 to 2018
$3.6M
NIAID NIH HHS U19 AI110491NIGMS NIH HHS T32 GM007365
6 · The paper itself

Abstract

Anti-cytokine autoantibodies (ACAAs) have been described in a growing number of primary immunodeficiencies with autoimmune features, including autoimmune polyendocrine syndrome type I (APS-1), a prototypical disease of defective T cell-mediated central tolerance. Whether defects in peripheral tolerance lead to similar ACAAs is unknown. Immunodysregulation polyendocrinopathy enteropathy X-linked (IPEX) is caused by mutations in

Indexed as

Antibodies, NeutralizingAutoantibodiesChildHumansImmunoglobulin GInfantInterferon-alphaPolyendocrinopathies, AutoimmuneAntibodies, NeutralizingAutoantibodiesImmunoglobulin GInterferon-alphaanti-cytokine autoantibodiesautoimmune polyendocrine syndrome type Iimmunodysregulation polyendocrinopathy enteropathy X-linkedinterferon-alphaprotein microarrays

Identifiers

PMID29651287
PMCPMC5885158
OpenAlexW2795242253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.