Evidence map›Paper›PMID 29651271›Full record

ArticleFrontiers in neurology2018

Genetics Modulate Gray Matter Variation Beyond Disease Burden in Prodromal Huntington's Disease.

Jingyu Liu, Jennifer Ciarochi, Vince D Calhoun, Jane S Paulsen, H Jeremy Bockholt, Hans J Johnson, Jeffrey D Long, Dongdong Lin, Flor A Espinoza, Maria B Misiura and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Jingyu LiuThe Mind Research Network & Lovelace Biomedical and Environmental Research Institute (LBERI), Albuquerque, NM, United States.
Jennifer CiarochiDepartment of Psychology, Georgia State University, Atlanta, GA, United States.
Vince D CalhounThe Mind Research Network & Lovelace Biomedical and Environmental Research Institute (LBERI), Albuquerque, NM, United States.
Jane S PaulsenDepartment of Psychiatry, University of Iowa, Iowa City, IA, United States.
H Jeremy BockholtDepartment of Psychiatry, University of Iowa, Iowa City, IA, United States.
Hans J JohnsonDepartment of Psychiatry, University of Iowa, Iowa City, IA, United States.
Jeffrey D LongDepartment of Psychiatry, University of Iowa, Iowa City, IA, United States.
Dongdong LinThe Mind Research Network & Lovelace Biomedical and Environmental Research Institute (LBERI), Albuquerque, NM, United States.
Flor A EspinozaThe Mind Research Network & Lovelace Biomedical and Environmental Research Institute (LBERI), Albuquerque, NM, United States.
Maria B MisiuraDepartment of Psychology, Georgia State University, Atlanta, GA, United States.
Arvind CaprihanThe Mind Research Network & Lovelace Biomedical and Environmental Research Institute (LBERI), Albuquerque, NM, United States.
Jessica A TurnerThe Mind Research Network & Lovelace Biomedical and Environmental Research Institute (LBERI), Albuquerque, NM, United States.
PREDICT-HD Investigators and Coordinators of the Huntington Study Group
Mind Research Network · USUniversity of Iowa · USGeorgia State University · USUniversity of New Mexico · US

Funding

NEUROBIOLOGICAL PREDICTORS OF HUNTINGTON'S DISEASER01NS040068 · NINDS · UNIVERSITY OF IOWA · PI PAULSEN, JANE S · 2001 to 2013
$48.5M
Cognitive and functional brain changes in preclinical Huntington's disease (HD)R01NS054893 · NINDS · UNIVERSITY OF IOWA · PI PAULSEN, JANE S · 2007 to 2011
$2.0M
Imaging and Genetics in Huntington's DiseaseU01NS082074 · NINDS · THE MIND RESEARCH NETWORK · PI CALHOUN, VINCE D, TURNER, JESS · 2013 to 2015
$1.4M
NINDS NIH HHS R01 NS040068NINDS NIH HHS R01 NS054893NINDS NIH HHS U01 NS082074
6 · The paper itself

Abstract

Huntington's disease (HD) is a neurodegenerative disorder caused by an expansion mutation of the cytosine-adenine-guanine (CAG) trinucleotide in the

Indexed as

cognitiongenetic modifiergray matterHuntington’s diseaseprodromal disease progression

Identifiers

PMID29651271
PMCPMC5884935
OpenAlexW2794925978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.