ArticleFrontiers in physiology2018
Sex-Specific Skeletal Muscle Fatigability and Decreased Mitochondrial Oxidative Capacity in Adult Rats Exposed to Postnatal Hyperoxia.
Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Impact of preterm birth on muscle mass and function: a systematic review and meta-analysis.European journal of pediatrics · 2024Pooled it
- Aerobic Exercise Training Response in Preterm-Born Young Adults with Elevated Blood Pressure and Stage 1 Hypertension: A Randomized Clinical Trial.American journal of respiratory and critical care medicine · 2023Trial
- Central and Peripheral Mechanisms of Low Exercise Capacity in Prematurely Born Adults.Comprehensive physiology · 2025Article
- Lung Function in a Multiethnic U.S. Cohort of Adolescents and Adults Born Preterm in the New BPD Era.Pediatric pulmonology · 2025Article
- Adults born preterm have lower peripheral skeletal muscle area and strength.Scientific reports · 2024Observational
- Microvascular and oxidative stress responses to acute high-altitude exposure in prematurely born adults.Scientific reports · 2023Article
- Respiratory responses to hypoxia during rest and exercise in individuals born pre-term: a state-of-the-art review.European journal of applied physiology · 2022Review
- Local Mucosal COFrontiers in medicine · 2022Article
- Effects of Hyperoxia on Mitochondrial Homeostasis: Are Mitochondria the Hub for Bronchopulmonary Dysplasia?Frontiers in cell and developmental biology · 2021Review
- Estrogen receptor-α prevents right ventricular diastolic dysfunction and fibrosis in female rats.American journal of physiology. Heart and circulatory physiology · 2020Article
- Sex differences in skeletal muscle alterations in a model of colorectal cancer.Physiological reports · 2020Article
- Bimodal right ventricular dysfunction after postnatal hyperoxia exposure: implications for the preterm heart.American journal of physiology. Heart and circulatory physiology · 2019Article
- Reduced handgrip and inspiratory muscle strength are associated with lower lung function and physical capacity in children and adolescents born preterm with very low birth weight.Brazilian journal of physical therapyArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Premature birth affects more than 10% of live births, and is characterized by relative hyperoxia exposure in an immature host. Long-term consequences of preterm birth include decreased aerobic capacity, decreased muscular strength and endurance, and increased prevalence of metabolic diseases such as type 2 diabetes mellitus. Postnatal hyperoxia exposure in rodents is a well-established model of chronic lung disease of prematurity, and also recapitulates the pulmonary vascular, cardiovascular, and renal phenotype of premature birth. The objective of this study was to evaluate whether postnatal hyperoxia exposure in rats could recapitulate the skeletal and metabolic phenotype of premature birth, and to characterize the subcellular metabolic changes associated with postnatal hyperoxia exposure, with a secondary aim to evaluate sex differences in this model. Compared to control rats, male rats exposed to 14 days of postnatal hyperoxia then aged to 1 year demonstrated higher skeletal muscle fatigability, lower muscle mitochondrial oxidative capacity, more mitochondrial damage, and higher glycolytic enzyme expression. These differences were not present in female rats with the same postnatal hyperoxia exposure. This study demonstrates detrimental mitochondrial and muscular outcomes in the adult male rat exposed to postnatal hyperoxia. Given that young adults born premature also demonstrate skeletal muscle dysfunction, future studies are merited to determine whether this dysfunction as well as reduced aerobic capacity is due to reduced mitochondrial oxidative capacity and metabolic dysfunction.
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