ArticleFrontiers in neuroscience2018
Tal1, Gata2a, and Gata3 Have Distinct Functions in the Development of V2b and Cerebrospinal Fluid-Contacting KA Spinal Neurons.
Article in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Transcriptional Regulators with Broad Expression in the Zebrafish Spinal Cord.bioRxiv : the preprint server for biology · 2024Article
- Roles of cerebrospinal fluid-contacting neurons as potential neural stem cells in the repair and regeneration of spinal cord injuries.Frontiers in cell and developmental biology · 2024Review
- Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells.Neural development · 2023Article
- Generation and application of endogenously floxed alleles for cell-specific knockout in zebrafish.Developmental cell · 2023Article
- Cerebrospinal fluid-contacting neurons: multimodal cells with diverse roles in the CNS.Nature reviews. Neuroscience · 2023Review
- Genome-wide association and replication studies for handedness in a Korean community-based cohort.Brain and behavior · 2023Article
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- Oscillating field stimulation promotes neurogenesis of neural stem cells through miR-124/Tal1 axis to repair spinal cord injury in rats.Neural regeneration research · 2023Article
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- Unique advantages of zebrafish larvae as a model for spinal cord regeneration.Frontiers in molecular neuroscience · 2022Review
- The Polycomb group geneFrontiers in neuroscience · 2022Article
- Fmrp regulates neuronal balance in embryonic motor circuit formation.Frontiers in neuroscience · 2022Article
- Back and forth: History of and new insights on the vertebrate lymphatic valve.Development, growth & differentiation · 2021Review
- A harmonized atlas of mouse spinal cord cell types and their spatial organization.Nature communications · 2021Article
- Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2.Cell reports · 2021Article
- Zygotic Vsx1 Plays a Key Role in Defining V2a Interneuron Sub-Lineage by Directly RepressingInternational journal of molecular sciences · 2020Article
- A single cell transcriptome atlas of the developing zebrafish hindbrain.Development (Cambridge, England) · 2020Article
- The Genetic Programs Specifying Kolmer-Agduhr Interneurons.Frontiers in neuroscience · 2020Review
- A GABAergic Maf-expressing interneuron subset regulates the speed of locomotion in Drosophila.Nature communications · 2019Article
- Article
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6 authors at 1 institution in 1 country.
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Abstract
Vertebrate locomotor circuitry contains distinct classes of ventral spinal cord neurons which each have particular functional properties. While we know some of the genes expressed by each of these cell types, we do not yet know how several of these neurons are specified. Here, we investigate the functions of Tal1, Gata2a, and Gata3 transcription factors in the development of two of these populations of neurons with important roles in locomotor circuitry: V2b neurons and cerebrospinal fluid-contacting Kolmer-Agduhr (KA) neurons (also called CSF-cNs). Our data provide the first demonstration, in any vertebrate, that Tal1 and Gata3 are required for correct development of KA and V2b neurons, respectively. We also uncover differences in the genetic regulation of V2b cell development in zebrafish compared to mouse. In addition, we demonstrate that Sox1a and Sox1b are expressed by KA and V2b neurons in zebrafish, which differs from mouse, where Sox1 is expressed by V2c neurons. KA neurons can be divided into ventral KA″ neurons and more dorsal KA' neurons. Consistent with previous morpholino experiments, our mutant data suggest that Tal1 and Gata3 are required in KA' but not KA″ cells, whereas Gata2a is required in KA″ but not KA' cells, even though both of these cell types co-express all three of these transcription factors. In
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.