ArticleNature communications2018
Design principles for enhancing phase sensitivity and suppressing phase fluctuations simultaneously in biochemical oscillatory systems.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Koopman mode decomposition of thermodynamic dissipation in nonlinear Langevin dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- How nature discovers rare Turing islands: Exploration by common limit cycles.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A fundamental trade-off among noise suppression, response sensitivity and speed in biological feedback networks.NPJ systems biology and applications · 2026Article
- How cells tame noise while maintaining ultrasensitive transcriptional responses.PLoS computational biology · 2025Article
- Stochastic thermodynamics for biological functions.Quantitative biology (Beijing, China) · 2025Review
- Time-reversal symmetry breaking in the chemosensory array reveals a general mechanism for dissipation-enhanced cooperative sensing.Nature communications · 2024Article
- Temperature compensation through kinetic regulation in biochemical oscillators.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Quantifying Landscape-Flux via Single-Cell Transcriptomics Uncovers the Underlying Mechanism of Cell Cycle.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The ups and downs of biological oscillators: a comparison of time-delayed negative feedback mechanisms.Journal of the Royal Society, Interface · 2023Article
- Network design principle for robust oscillatory behaviors with respect to biological noise.eLife · 2022Article
- Eukaryotic gene regulation at equilibrium, or non?Current opinion in systems biology · 2022Article
- Principles, mechanisms and functions of entrainment in biological oscillators.Interface focus · 2022Review
- A strong nonequilibrium bound for sorting of cross-linkers on growing biopolymers.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Physical bioenergetics: Energy fluxes, budgets, and constraints in cells.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Inverse Power Law Scaling of Energy Dissipation Rate in Nonequilibrium Reaction Networks.Physical review letters · 2021Article
- Irreversibility in dynamical phases and transitions.Nature communications · 2021Article
- Stochastic Dynamics of Gene Switching and Energy Dissipation for Gene Expression.Frontiers in genetics · 2020Article
- The energy cost and optimal design for synchronization of coupled molecular oscillators.Nature physics · 2020Article
- The thermodynamic uncertainty relation in biochemical oscillations.Journal of the Royal Society, Interface · 2019Article
- Waveforms of molecular oscillations reveal circadian timekeeping mechanisms.Communications biology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Biological systems need to function accurately in the presence of strong noise and at the same time respond sensitively to subtle external cues. Here we study design principles in biochemical oscillatory circuits to achieve these two seemingly incompatible goals. We show that energy dissipation can enhance phase sensitivity linearly by driving the phase-amplitude coupling and increase timing accuracy by suppressing phase diffusion. Two general design principles in the key underlying reaction loop formed by two antiparallel pathways are found to optimize oscillation performance with a given energy budget: balancing the forward-to-backward flux ratio between the two pathways to reduce phase diffusion and maximizing the net flux of the phase-advancing pathway relative to that of the phase-retreating pathway to enhance phase sensitivity. Experimental evidences consistent with these design principles are found in the circadian clock of cyanobacteria. Future experiments to test the predicted dependence of phase sensitivity on energy dissipation are proposed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.