ArticleScientific reports2018
Diversity and bioactive potential of culturable fungal endophytes of Dysosma versipellis; a rare medicinal plant endemic to China.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers.
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34 citing papers in PubMed, 95 citations in OpenAlex.
- Functional characterization of fungal endophytes with antagonistic and plant growth-promoting activities in maize.Scientific reports · 2026Article
- Characterization of an Endophytic Fusarium odoratissimum Strain 25Current microbiology · 2026Article
- Unravelling the fungal endomicrobiome of Picrorhiza kurrooa for increasing in-planta picroside biosynthesis using endophytic Trichoderma harzianum PKRF1.Environmental microbiome · 2026Article
- Comprehensive review of tujia "Lian" medicinal botanical drugs: traditional classification system, phytochemical, and pharmacological profile.Frontiers in pharmacology · 2026Review
- Highly diverse endophytic fungi from Serra do Amolar-Pantanal (Brazil) producing bioactive secondary metabolites against phytopathogens.Frontiers in microbiology · 2024Article
- Potential mechanisms underlying podophyllotoxin-induced cardiotoxicity in male rats: toxicological evidence chain (TEC) concept.Frontiers in pharmacology · 2024Article
- The anticancer and antibacterial potential of bioactive secondary metabolites derived From bacterial endophytes in association with Artemisia absinthium.Scientific reports · 2023Article
- Review
- Plants as the Extended Phenotype of Endophytes-The Actual Source of Bioactive Compounds.International journal of molecular sciences · 2023Review
- Diversity, Lifestyle, Genomics, and Their Functional Role ofJournal of fungi (Basel, Switzerland) · 2023Review
- Antioxidant, Cytotoxic, and DNA Damage Protection Activities of Endophytic FungusMicroorganisms · 2023Article
- Structurally diverse biflavonoids fromRSC advances · 2022Article
- Cultivable endophytic fungal community associated with the karst endemic plantFrontiers in microbiology · 2022Article
- Bioactive potentiality of secondary metabolites from endophytic bacteria against SARS-COV-2: An in-silico approach.PloS one · 2022Article
- Phosphate solubilizing microorganisms isolated from medicinal plants improve growth of mint.PeerJ · 2022Article
- Potential Multifunctional Bioactive Compounds fromJournal of inflammation research · 2022Article
- Isolation and Cytotoxic Potency of Endophytic Fungi Associated withMycobiology · 2022Article
- Fungal Endophytes: A Promising Frontier for Discovery of Novel Bioactive Compounds.Journal of fungi (Basel, Switzerland) · 2021Review
- Diversity, Phylogeny and Antagonistic Activity of Fungal Endophytes Associated with Endemic Species ofJournal of fungi (Basel, Switzerland) · 2021Article
- Podophyllotoxin: History, Recent Advances and Future Prospects.Biomolecules · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plant Dysosma versipellis is known for its antimicrobial and anticancer properties but is a rare and vulnerable perennial herb that is endemic to China. In this study, 224 isolates were isolated from various tissues of D. versipellis, and were classified into 53 different morphotypes according to culture characteristics and were identified by sequence analyses of the internal transcribed spacer (ITS) region of the rRNA gene. Although nine strains were not assignable at the phylum level, 44 belonged to at least 29 genera of 15 orders of Ascomycota (93%), Basidiomycota (6%), and Zygomycota (1%). Subsequent assays revealed antimicrobial activities of 19% of endophytic extracts against at least one pathogenic bacterium or fungus. Antimicrobial activity was also determined using the agar diffusion method and was most prominent in extracts from four isolates. Moreover, high performance liquid chromatography (HPLC) and ultra-performance liquid chromatography-quadrupole-time of flight mass spectrometry analyses (UPLC-QTOF MS) showed the presence of podophyllotoxin in two Fusarium strains, with the highest yield of 277 μg/g in Fusarium sp. (WB5121). Taken together, the present data suggest that various endophytic fungi of D. versipellis could be exploited as sources of novel natural antimicrobial or anticancer agents.
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