Evidence map›Paper›PMID 29651002›Full record

ArticleScientific reports2018

Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model.

Hui-Hua Chang, Aune Moro, Caroline Ei Ne Chou, David W Dawson, Samuel French, Andrea I Schmidt, James Sinnett-Smith, Fang Hao, O Joe Hines, Guido Eibl and 1 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

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  9. Dietary fat and lipid metabolism in the tumor microenvironment.Biochimica et biophysica acta. Reviews on cancer · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Hui-Hua ChangDepartment of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID 0000-0001-6369-0326
Aune MoroDepartment of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Caroline Ei Ne ChouDepartment of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
David W DawsonDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Samuel FrenchDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID 0000-0002-7611-881X
Andrea I SchmidtDepartment of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
James Sinnett-SmithDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Fang HaoDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
O Joe HinesDepartment of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Guido EiblDepartment of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. GEibl@mednet.ucla.edu.ORCID 0000-0003-3497-4527
Enrique RozengurtDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
University of California, Los Angeles · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
Targeting diet-induced promotion of Kras-initiated pancreatic adenocarcinomaP01CA163200 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PANDOL, STEPHEN J. · 2012 to 2016
$6.2M
PKD1 Signaling and Crosstalk Mechanisms in Intestinal Epithelial Cell RegulationR01DK100405 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 2014 to 2017
$1.3M
NCI NIH HHS P01 CA163200NCI NIH HHS P30 CA016042NIDDK NIH HHS P30 DK041301NIDDK NIH HHS R01 DK100405
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a particularly deadly disease. Chronic conditions, including obesity and type-2 diabetes are risk factors, thus making PDAC amenable to preventive strategies. We aimed to characterize the chemo-preventive effects of metformin, a widely used anti-diabetic drug, on PDAC development using the Kras

Indexed as

AcyltransferasesAdministration, OralAnimalsCarcinogenesisCarcinoma, Pancreatic DuctalChemopreventionDiet, High-FatDisease Models, AnimalDrinking WaterFatty LiverFemaleGene Expression RegulationHumansHyperinsulinismMaleMechanistic Target of Rapamycin Complex 1AcyltransferasesDrinking WaterHras protein, mouseMapk1 protein, mouseMechanistic Target of Rapamycin Complex 1MetforminMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Proto-Oncogene Proteins p21(ras)tafazzin protein, mouseTranscription Factors

Identifiers

PMID29651002
PMCPMC5897574
OpenAlexW2806664701

What OpenQuestion holds

Textfull text, public
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.