Evidence map›Paper›PMID 29650946›Full record

ArticleThe American journal of case reports2018

A Rare Case of Relapsed Pediatric Acute Promyelocytic Leukemia with Skin Involvement by Myeloid Sarcoma.

Nathalia Silva Araújo, Claudio José Dos Santos Júnior, Vitória Mikaelly da Silva Gomes, Luiz Arthur Calheiros Leite, Luana Novaes Bomfim, Amanda Katielly Firmino da Silva Gusmão, Maria Jordana Rocha Gomes Alves, Cyndi Myrelle da Silva Barros Romão, Arthur Moacir Costa Sampaio Batinga, Maria Rosa da Silva and 1 more

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Leukaemia cutis for clinicians, a literature review.Postepy dermatologii i alergologii · 2021
    Review
  2. Advances in Pediatric Acute Promyelocytic Leukemia.Children (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Nathalia Silva AraújoCenter for Oncology, Santa Casa de Misericórdia de Maceió, Maceió, AL, Brazil.
Claudio José Dos Santos JúniorState University of Health Sciences of Alagoas (UNCISAL), Maceió, AL, Brazil.
Vitória Mikaelly da Silva GomesFaculty of Medicine, Federal University of Alagoas (UFAL), Maceió, AL, Brazil.
Luiz Arthur Calheiros LeiteState University of Health Sciences of Alagoas (UNCISAL), Maceió, AL, Brazil.
Luana Novaes BomfimCenter for Oncology, Santa Casa de Misericórdia de Maceió, Maceió, AL, Brazil.
Amanda Katielly Firmino da Silva GusmãoCenter for Oncology, Santa Casa de Misericórdia de Maceió, Maceió, AL, Brazil.
Maria Jordana Rocha Gomes AlvesState University of Health Sciences of Alagoas (UNCISAL), Maceió, AL, Brazil.
Cyndi Myrelle da Silva Barros RomãoState University of Health Sciences of Alagoas (UNCISAL), Maceió, AL, Brazil.
Arthur Moacir Costa Sampaio BatingaFaculty of Medicine, Federal University of Alagoas (UFAL), Maceió, AL, Brazil.
Maria Rosa da SilvaState University of Health Sciences of Alagoas (UNCISAL), Maceió, AL, Brazil.
Célio Fernando de Sousa RodriguesDepartment of Anatomy, State University of Health Sciences of Alagoas (UNCISAL), Maceió, AL, Brazil.
Universidade Estadual de Ciências da Saúde de Alagoas · BRSanta Casa de Misericórdia de Marília · BRUniversidade Federal de Alagoas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND Acute promyelocytic leukemia (APL) is a very rare leukemia in children. Extramedullary involvement by APL has been reported in between 3-5% of cases, mainly associated with cases of relapse. A rare case of relapse of APL in a 9-year-old child is presented with skin involvement with myeloid sarcoma. CASE REPORT A 9-year-old male child was admitted to the Oncology Service of the hospital complaining of fever, progressive fatigue, oral petechiae with severe bleeding in the oral cavity. Bone marrow examination showed some promyelocytes. Flow cytometry showed 86% immature myeloid cells with the t(15;17) translocation, and molecular analysis showed expression of the PML/RARa fusion protein, which confirmed the diagnosis of APL. The patient completed a course of daunorubicin, cytarabine, and AII trans-retinoic acid (ATRA) with complete remission. After six months, the patient was re-admitted to hospital with a violaceous lesion on the scalp, with relapse of APL. Histological and immunohistochemistry of the lesion involving the skin of the scalp showed a myeloid sarcoma invading the dermis. CONCLUSIONS Myeloid sarcoma, also called granulocytic sarcoma, is an extramedullary tumor of immature myeloid cells, which very rarely presents in children with APL. The mechanisms that lead to myeloid sarcoma in children with APL and the possible association with ATRA therapy remain to be investigated.

Indexed as

Rare DiseasesScalpBiopsyChildFatal OutcomeFlow CytometryHumansLeukemia, Promyelocytic, AcuteMaleMyeloid CellsSarcoma, MyeloidSkin Neoplasms

Identifiers

PMID29650946
PMCPMC5912010
OpenAlexW2798247269

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.