Evidence map›Paper›PMID 29650791›Full record

ArticleCirculation. Cardiovascular imaging2018

Impairments in Adipose Tissue Microcirculation in Type 2 Diabetes Mellitus Assessed by Real-Time Contrast-Enhanced Ultrasound.

Donghua Hu, Devika Remash, Ryan D Russell, Timothy Greenaway, Stephen Rattigan, Kathryn A Squibb, Graeme Jones, Dino Premilovac, Stephen M Richards, Michelle A Keske

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Circulation. Cardiovascular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 36 citations in OpenAlex.

  1. Trial
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  6. Review
  7. Prospects of potential adipokines as therapeutic agents in obesity-linked atherogenic dyslipidemia and insulin resistance.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2023
    Review
  8. Hemodynamics and Arterial Stiffness in Response to Oral Glucose Loading in Individuals with Type II Diabetes and Controlled Hypertension.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2023
    Article
  9. Article
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  13. Transcranial contrast-enhanced ultrasound in the rat brain reveals substantial hyperperfusion acutely post-stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Donghua HuMenzies Institute for Medical Research (D.H., R.D.R., S.R., K.A.S., G.J., S.M.R., M.A.K.) and School of Medicine (D.R., T.G., D.P., S.M.R.), University of Tasmania, Hobart, TAS Australia; Department of Health and Human Performance, College of Health Services, University of Texas Rio Grande Valley, Brownsville TX, (R.D.R.); Royal Hobart Hospital, TAS, Australia (T.G.); Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia (M.A.K.); and Department of Pharmacology, Anhui Medical University, Hefei, China (D.H.).
Devika RemashMenzies Institute for Medical Research (D.H., R.D.R., S.R., K.A.S., G.J., S.M.R., M.A.K.) and School of Medicine (D.R., T.G., D.P., S.M.R.), University of Tasmania, Hobart, TAS Australia; Department of Health and Human Performance, College of Health Services, University of Texas Rio Grande Valley, Brownsville TX, (R.D.R.); Royal Hobart Hospital, TAS, Australia (T.G.); Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia (M.A.K.); and Department of Pharmacology, Anhui Medical University, Hefei, China (D.H.).
Ryan D RussellMenzies Institute for Medical Research (D.H., R.D.R., S.R., K.A.S., G.J., S.M.R., M.A.K.) and School of Medicine (D.R., T.G., D.P., S.M.R.), University of Tasmania, Hobart, TAS Australia; Department of Health and Human Performance, College of Health Services, University of Texas Rio Grande Valley, Brownsville TX, (R.D.R.); Royal Hobart Hospital, TAS, Australia (T.G.); Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia (M.A.K.); and Department of Pharmacology, Anhui Medical University, Hefei, China (D.H.).
Timothy GreenawayMenzies Institute for Medical Research (D.H., R.D.R., S.R., K.A.S., G.J., S.M.R., M.A.K.) and School of Medicine (D.R., T.G., D.P., S.M.R.), University of Tasmania, Hobart, TAS Australia; Department of Health and Human Performance, College of Health Services, University of Texas Rio Grande Valley, Brownsville TX, (R.D.R.); Royal Hobart Hospital, TAS, Australia (T.G.); Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia (M.A.K.); and Department of Pharmacology, Anhui Medical University, Hefei, China (D.H.).
Stephen RattiganMenzies Institute for Medical Research (D.H., R.D.R., S.R., K.A.S., G.J., S.M.R., M.A.K.) and School of Medicine (D.R., T.G., D.P., S.M.R.), University of Tasmania, Hobart, TAS Australia; Department of Health and Human Performance, College of Health Services, University of Texas Rio Grande Valley, Brownsville TX, (R.D.R.); Royal Hobart Hospital, TAS, Australia (T.G.); Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia (M.A.K.); and Department of Pharmacology, Anhui Medical University, Hefei, China (D.H.).
Kathryn A SquibbMenzies Institute for Medical Research (D.H., R.D.R., S.R., K.A.S., G.J., S.M.R., M.A.K.) and School of Medicine (D.R., T.G., D.P., S.M.R.), University of Tasmania, Hobart, TAS Australia; Department of Health and Human Performance, College of Health Services, University of Texas Rio Grande Valley, Brownsville TX, (R.D.R.); Royal Hobart Hospital, TAS, Australia (T.G.); Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia (M.A.K.); and Department of Pharmacology, Anhui Medical University, Hefei, China (D.H.).
Graeme JonesMenzies Institute for Medical Research (D.H., R.D.R., S.R., K.A.S., G.J., S.M.R., M.A.K.) and School of Medicine (D.R., T.G., D.P., S.M.R.), University of Tasmania, Hobart, TAS Australia; Department of Health and Human Performance, College of Health Services, University of Texas Rio Grande Valley, Brownsville TX, (R.D.R.); Royal Hobart Hospital, TAS, Australia (T.G.); Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia (M.A.K.); and Department of Pharmacology, Anhui Medical University, Hefei, China (D.H.).
Dino PremilovacMenzies Institute for Medical Research (D.H., R.D.R., S.R., K.A.S., G.J., S.M.R., M.A.K.) and School of Medicine (D.R., T.G., D.P., S.M.R.), University of Tasmania, Hobart, TAS Australia; Department of Health and Human Performance, College of Health Services, University of Texas Rio Grande Valley, Brownsville TX, (R.D.R.); Royal Hobart Hospital, TAS, Australia (T.G.); Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia (M.A.K.); and Department of Pharmacology, Anhui Medical University, Hefei, China (D.H.).
Stephen M RichardsMenzies Institute for Medical Research (D.H., R.D.R., S.R., K.A.S., G.J., S.M.R., M.A.K.) and School of Medicine (D.R., T.G., D.P., S.M.R.), University of Tasmania, Hobart, TAS Australia; Department of Health and Human Performance, College of Health Services, University of Texas Rio Grande Valley, Brownsville TX, (R.D.R.); Royal Hobart Hospital, TAS, Australia (T.G.); Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia (M.A.K.); and Department of Pharmacology, Anhui Medical University, Hefei, China (D.H.).
Michelle A KeskeMenzies Institute for Medical Research (D.H., R.D.R., S.R., K.A.S., G.J., S.M.R., M.A.K.) and School of Medicine (D.R., T.G., D.P., S.M.R.), University of Tasmania, Hobart, TAS Australia; Department of Health and Human Performance, College of Health Services, University of Texas Rio Grande Valley, Brownsville TX, (R.D.R.); Royal Hobart Hospital, TAS, Australia (T.G.); Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia (M.A.K.); and Department of Pharmacology, Anhui Medical University, Hefei, China (D.H.). Michelle.Keske@deakin.edu.au.
The University of Texas Rio Grande Valley · USDeakin University · AURoyal Hobart Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn obesity and type 2 diabetes mellitus (T2D), adipose tissue expansion (because of larger adipocytes) results in reduced microvascular density which is thought to lead to adipocyte hypoxia, inflammation, and reduced nutrient delivery to the adipocyte. Adipose tissue microvascular responses in humans with T2D have not been extensively characterized. Furthermore, it has not been determined whether impaired microvascular responses in human adipose tissue are most closely associated with adiposity, inflammation, or altered metabolism. METHODS AND

resultsOvernight-fasted healthy controls (n=24, 9 females/15 males) and people with T2D (n=21, 8 females/13 males) underwent a body composition scan (dual-energy X-ray absorptiometry), an oral glucose challenge (50 g glucose) and blood analysis of clinical chemistries and inflammatory markers. Abdominal subcutaneous adipose tissue microvascular responses were measured by contrast-enhanced ultrasound at baseline and 1-hour post-oral glucose challenge. Adipose tissue microvascular blood volume was significantly elevated in healthy subjects 1-hour post-oral glucose challenge; however, this effect was absent in T2D. Adipose tissue microvascular blood flow was lower in people with T2D at baseline and was significantly blunted post-oral glucose challenge compared with controls. Adipose tissue microvascular blood flow was negatively associated with truncal fat (%), glucoregulatory function, fasting triglyceride and nonesterified fatty acid levels, and positively associated with insulin sensitivity. Truncal fat (%), systolic blood pressure, and insulin sensitivity were the only correlates with microvascular blood volume. Systemic inflammation was not associated with adipose tissue microvascular responses.

conclusionsImpaired microvascular function in adipose tissue during T2D is not conditionally linked to systemic inflammation but is associated with other characteristics of the metabolic syndrome (obesity, insulin resistance, hyperglycemia, and dyslipidemia).

Indexed as

MicrocirculationAbsorptiometry, PhotonAdipose TissueAdultBiomarkersBody CompositionContrast MediaDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedUltrasonographyBiomarkersContrast Mediablood volumediabetes mellitus, type 2insulin resistancemetabolismmicrocirculationobesity

Identifiers

PMID29650791
OpenAlexW2797633678

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.