ArticleAJNR. American journal of neuroradiology2018
Differentiating Atypical Hemangiomas and Metastatic Vertebral Lesions: The Role of T1-Weighted Dynamic Contrast-Enhanced MRI.
Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 63 citations in OpenAlex.
- Perfusion characterization of osteosarcoma spinal metastases using advanced T1-weighted dynamic contrast enhanced MRI.Skeletal radiology · 2026Article
- MR spectroscopy in differentiating spinal atypical hemangioma from metastasis: preliminary results.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Case Report: Repeated imaging and surgical treatment of a vascular hamartoma arising from the cervical vertebral column of a cat.Frontiers in veterinary science · 2026Article
- Multiparametric spinal MRI for differentiating benign and malignant vertebral compression fractures.Radiologie (Heidelberg, Germany) · 2025Article
- Sacral tumors: a comprehensive review of imaging, diagnostic challenges, and tumor mimics.Skeletal radiology · 2025Review
- Revisiting Fat Content in Bone Lesions: Paradigms in Bone Lesion Detection.Diseases (Basel, Switzerland) · 2025Review
- PSMA-expressing, fluciclovine-negative vertebral hemangioma.EJNMMI research · 2025Article
- Comprehensive Review of the Utility of Dynamic Contrast-Enhanced MRI for the Diagnosis and Treatment Assessment of Spinal Benign and Malignant Osseous Disease.AJNR. American journal of neuroradiology · 2025Review
- Aggressive giant dumbell-shaped thoracic vertebral hemangioma: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Vertebral hemangiomas: a review on diagnosis and management.Journal of orthopaedic surgery and research · 2024Review
- T1-Weighted, Dynamic Contrast-Enhanced MR Perfusion Imaging Can Differentiate between Treatment Success and Failure in Spine Metastases Undergoing Radiation Therapy.AJNR. American journal of neuroradiology · 2023Article
- Intense PSMA Uptake in a Vertebral Hemangioma Mimicking a Solitary Bone Metastasis in the Primary Staging of Prostate Cancer viaDiagnostics (Basel, Switzerland) · 2023Article
- Management of Aggressive Vertebral Haemangioma and Assessment of Differentiating Pointers Between Aggressive Vertebral Haemangioma and Metastases - A Systematic Review.Global spine journal · 2023Review
- Article
- Precise differentiation between jugular foramen paragangliomas and metastases: utility of diffusion-weighted and dynamic contrast-enhanced magnetic resonance imaging.Neuroradiology · 2023Article
- Atypical Vertebral Hemangioma in a Patient With Newly Diagnosed Pulmonary Nodule.Annals of thoracic surgery short reports · 2023Article
- Vertebral Hemangiomas: Prevalence, new classification and natural history. magnetic resonance imaging-based retrospective longitudinal study.The neuroradiology journal · 2023Article
- Skull metastases and osseous venous malformations: The role of diffusion-weighted and dynamic contrast-enhanced MRI.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
- Multidisciplinary management of spinal metastases: what the radiologist needs to know.The British journal of radiology · 2022Review
- Imaging for Plasma Cell Dyscrasias: What, When, and How?Frontiers in oncology · 2022Review
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
Abstract
background and purposeVertebral hemangiomas are benign vascular lesions that are almost always incidentally found in the spine. Their classic typical hyperintense appearance on T1- and T2-weighted MR images is diagnostic. Unfortunately, not all hemangiomas have the typical appearance, and they can mimic metastases on routine MR imaging. These are generally referred to as atypical hemangiomas and can result in misdiagnosis and ultimately additional imaging, biopsy, and unnecessary costs. Our objective was to assess the utility of dynamic contrast-enhanced MR imaging perfusion in distinguishing vertebral atypical hemangiomas and malignant vertebral metastases. We hypothesized that permeability and vascular density will be increased in metastases compared with atypical hemangiomas. MATERIALS AND
methodsConsecutive patients from 2011 to 2015 with confirmed diagnoses of atypical hemangiomas and spinal metastases from breast and lung carcinomas with available dynamic contrast-enhanced MR imaging were analyzed. Time-intensity curves were qualitatively compared among the groups. Perfusion parameters, plasma volume, and permeability constant were quantified using an extended Tofts 2-compartment pharmacokinetic model. Statistical significance was tested using the Mann-Whitney
resultsQualitative inspection of dynamic contrast-enhanced MR imaging time-intensity curves demonstrated differences in signal intensity and morphology between metastases and atypical hemangiomas. Quantitative analysis of plasma volume and permeability constant perfusion parameters showed significantly higher values in metastatic lesions compared with atypical hemangiomas (
conclusionsOur data demonstrate that plasma volume and permeability constant perfusion parameters and qualitative inspection of contrast-enhancement curves can be used to differentiate atypical hemangiomas from vertebral metastatic lesions. This work highlights the benefits of adding perfusion maps to conventional sequences to improve diagnostic accuracy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.